| Literature DB >> 14684302 |
Xubo Hu1, Jinge Zhu, Sumant Srivathsan, Dehua Pei.
Abstract
A new class of methionine aminopeptidase (MetAP) inhibitors, which contain an internal hydroxamate (N-acyl-N-alkylhydroxylamine) core as the metal-chelating group, has been designed, synthesized, and tested. The compounds exhibited reversible, competitive inhibition against Escherichia coli MetAP as well as human MetAP-1 and MetAP-2. The most potent inhibitor had a K(i) value of 2.5 microM and >20-fold selectivity toward E. coli MAP.Entities:
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Year: 2004 PMID： 14684302 DOI： 10.1016/j.bmcl.2003.10.031
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823