Edward A Neuwelt1. 1. Department of Neurology, Oregon Health & Science University, Portland, Oregon 97201, USA. neuwelte@ohsu.edu
Abstract
OBJECTIVE: The blood-brain barrier (BBB) is often perceived as a passive membrane. However, evidence has demonstrated that the BBB plays an active role in normal homeostasis and in certain disease processes. METHODS: Approximately 300 peer-reviewed publications that discussed normal or abnormal BBB function were reviewed. RESULTS: The role of the BBB and how it contributes to disorders of the central nervous system vary, depending on the specific disease process. CONCLUSION: In health and disease and extending to old age, endothelial cells, neurons, and glia constitute a neurovascular unit that regulates the BBB. Advances toward penetrating the BBB must account for both normal and abnormal functions of the neurovascular unit.
OBJECTIVE: The blood-brain barrier (BBB) is often perceived as a passive membrane. However, evidence has demonstrated that the BBB plays an active role in normal homeostasis and in certain disease processes. METHODS: Approximately 300 peer-reviewed publications that discussed normal or abnormal BBB function were reviewed. RESULTS: The role of the BBB and how it contributes to disorders of the central nervous system vary, depending on the specific disease process. CONCLUSION: In health and disease and extending to old age, endothelial cells, neurons, and glia constitute a neurovascular unit that regulates the BBB. Advances toward penetrating the BBB must account for both normal and abnormal functions of the neurovascular unit.
Authors: Sadhana Jackson; Nicole M Anders; Antonella Mangraviti; Teresia M Wanjiku; Eric W Sankey; Ann Liu; Henry Brem; Betty Tyler; Michelle A Rudek; Stuart A Grossman Journal: J Neurooncol Date: 2015-12-01 Impact factor: 4.130
Authors: Sebastian A Lewandowski; Ingrid Nilsson; Linda Fredriksson; Peter Lönnerberg; Lars Muhl; Manuel Zeitelhofer; Milena Z Adzemovic; Susanne Nichterwitz; Daniel A Lawrence; Eva Hedlund; Ulf Eriksson Journal: Acta Neuropathol Date: 2015-12-19 Impact factor: 17.088