| Literature DB >> 14682774 |
Abstract
Lewis acid activated donor-acceptor cyclopropanes react with aliphatic, aromatic, and alpha,beta-unsaturated nitriles in a novel cascade [3 + 2] dipolar cycloaddition, dehydration, and tautomerization sequence to afford pyrroles in moderate to excellent overall yield. This cost-effective and regiospecific method is ideally suited for the preparation of combinatorial libraries. [reaction: see text]Entities:
Year: 2003 PMID： 14682774 DOI： 10.1021/ol036180+
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005