Literature DB >> 1468115

Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNA.

C C Maier1, B Marchetti, R D LeBoeuf, J E Blalock.   

Abstract

1. A luteinizing hormone-releasing hormone (LHRH)-like molecule produced by thymocytes is similar to hypothalamic LHRH in both bioactivity and antigenicity. 2. We determined whether this thymic LHRH is identical to or only homologous with hypothalamic LHRH by synthesizing and sequencing the cDNA of rat thymus LHRH. 3. The thymocyte and hypothalamic LHRH cDNAs are identical, indicating, that the amino acid sequences of LHRH produced in the hypothalamus and the immune system are also identical. 4. This is the first report showing conclusively that cell of the immune system transcribe the authentic mRNA for a hypothalamic releasing factor, LHRH.

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Year:  1992        PMID： 1468115     DOI： 10.1007/bf00711545

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  15 in total

1.  The rat gonadotropin-releasing hormone: SH locus: structure and hypothalamic expression.

Authors:  C T Bond; J S Hayflick; P H Seeburg; J P Adelman
Journal:  Mol Endocrinol       Date:  1989-08

2.  Luteinizing hormone-releasing hormone signaling at the lymphocyte involves stimulation of interleukin-2 receptor expression.

Authors:  N Batticane; M C Morale; F Gallo; Z Farinella; B Marchetti
Journal:  Endocrinology       Date:  1991-07       Impact factor: 4.736

3.  Nucleotide and amino acid sequence of lymphocyte-derived corticotropin: endotoxin induction of a truncated peptide.

Authors:  E M Smith; F S Galin; R D LeBoeuf; D H Coppenhaver; D V Harbour; J E Blalock
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

4.  Immunoreactive growth hormone-releasing hormone in rat leukocytes.

Authors:  D A Weigent; J E Blalock
Journal:  J Neuroimmunol       Date:  1990 Sep-Oct       Impact factor: 3.478

5.  Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta.

Authors:  S Radovick; F E Wondisford; Y Nakayama; M Yamada; G B Cutler; B D Weintraub
Journal:  Mol Endocrinol       Date:  1990-03

6.  Rat spleen lymphocytes contain an immunoactive and bioactive luteinizing hormone-releasing hormone.

Authors:  N V Emanuele; M A Emanuele; J Tentler; L Kirsteins; N Azad; A M Lawrence
Journal:  Endocrinology       Date:  1990-05       Impact factor: 4.736

7.  Luteinizing hormone-releasing hormone (LHRH) agonist restoration of age-associated decline of thymus weight, thymic LHRH receptors, and thymocyte proliferative capacity.

Authors:  B Marchetti; V Guarcello; M C Morale; G Bartoloni; F Raiti; G Palumbo; Z Farinella; S Cordaro; U Scapagnini
Journal:  Endocrinology       Date:  1989-08       Impact factor: 4.736

8.  Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat.

Authors:  J P Adelman; A J Mason; J S Hayflick; P H Seeburg
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

9.  Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

Authors:  H Aviv; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

10.  Blockade of central and peripheral luteinizing hormone-releasing hormone (LHRH) receptors in neonatal rats with a potent LHRH-antagonist inhibits the morphofunctional development of the thymus and maturation of the cell-mediated and humoral immune responses.

Authors:  M C Morale; N Batticane; G Bartoloni; V Guarcello; Z Farinella; M G Galasso; B Marchetti
Journal:  Endocrinology       Date:  1991-02       Impact factor: 4.736
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  5 in total

1.  Mast cells in the rat brain synthesize gonadotropin-releasing hormone.

Authors:  Mona H Khalil; Ann-Judith Silverman; Rae Silver
Journal:  J Neurobiol       Date:  2003-08

2.  Neuroendocrineimmunology (NEI) at the turn of the century: towards a molecular understanding of basic mechanisms and implications for reproductive physiopathology.

Authors:  B Marchetti; M C Morale; F Gallo; N Batticane; Z Farinella; M Cioni
Journal:  Endocrine       Date:  1995-12       Impact factor: 3.633

3.  Cross-talk between luteinizing hormone-releasing hormone (LHRH) neurons and astroglial cells: developing glia release factors that accelerate neuronal differentiation and stimulate LHRH release from GT(1-1) neuronal cell line and LHRH neurons induce astroglia proliferation.

Authors:  F Gallo; M C Morale; R Avola; B Marchetti
Journal:  Endocrine       Date:  1995-12       Impact factor: 3.633

4.  The forkhead transcription factor, FOXP3, is required for normal pituitary gonadotropin expression in mice.

Authors:  Deborah O Jung; Jake S Jasurda; Noboru Egashira; Buffy S Ellsworth
Journal:  Biol Reprod       Date:  2012-05-10       Impact factor: 4.285

5.  Hypothalamic neurohormones and immune responses.

Authors:  J Luis Quintanar; Irene Guzmán-Soto
Journal:  Front Integr Neurosci       Date:  2013-08-13
  5 in total

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