Literature DB >> 14680206

Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids.

Chris M McGinley1, Wilfred A van der Donk.   

Abstract

The oxidation of polyunsaturated fatty acids such as arachidonic and linoleic acid initiates a plethora of cell signaling pathways in animals and plants. The chemistry of the enzymatic oxidation has been investigated for several enzymes, most notably prostaglandin synthase and the lipoxygenases, revealing many surprises and impressive examples of enzymatic control of hydrogen atom abstraction and subsequent oxygenation.

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Year:  2003        PMID： 14680206     DOI： 10.1039/b311008g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  13 in total

1.  Synthesis, structural studies, and oxidation catalysis of the manganese(II), iron(II), and copper(II) complexes of a 2-pyridylmethyl pendant armed side-bridged cyclam.

Authors:  Anthony D Shircliff; Kevin R Wilson; Desiray J Cannon; Donald G Jones; Zhan Zhang; Zhuqi Chen; Guochuan Yin; Timothy J Prior; Timothy J Hubin
Journal:  Inorg Chem Commun       Date:  2015-09-01       Impact factor: 2.495

2.  Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases.

Authors:  Cyril Jacquot; Aaron T Wecksler; Chris M McGinley; Erika N Segraves; Theodore R Holman; Wilfred A van der Donk
Journal:  Biochemistry       Date:  2008-06-12       Impact factor: 3.162

3.  Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation.

Authors:  Shauna Hill; Connor R Lamberson; Libin Xu; Randy To; Hui S Tsui; Vadim V Shmanai; Andrei V Bekish; Agape M Awad; Beth N Marbois; Charles R Cantor; Ned A Porter; Catherine F Clarke; Mikhail S Shchepinov
Journal:  Free Radic Biol Med       Date:  2012-06-15       Impact factor: 7.376

Review 4.  Applications of stereospecifically-labeled Fatty acids in oxygenase and desaturase biochemistry.

Authors:  Alan R Brash; Claus Schneider; Mats Hamberg
Journal:  Lipids       Date:  2011-10-05       Impact factor: 1.880

5.  Synthesis of site-specifically deuterated arachidonic acid derivatives containing a remote tritium radiolabel.

Authors:  Chris M McGinley; Wilfred A van der Donk
Journal:  J Labelled Comp Radiopharm       Date:  2006-05-17       Impact factor: 1.921

Review 6.  Biosynthesis and function of polyacetylenes and allied natural products.

Authors:  Robert E Minto; Brenda J Blacklock
Journal:  Prog Lipid Res       Date:  2008-03-13       Impact factor: 16.195

Review 7.  Cytochrome c/cardiolipin relations in mitochondria: a kiss of death.

Authors:  Valerian E Kagan; Hülya A Bayir; Natalia A Belikova; Olexandr Kapralov; Yulia Y Tyurina; Vladimir A Tyurin; Jianfei Jiang; Detcho A Stoyanovsky; Peter Wipf; Patrick M Kochanek; Joel S Greenberger; Bruce Pitt; Anna A Shvedova; Grigory Borisenko
Journal:  Free Radic Biol Med       Date:  2009-03-12       Impact factor: 7.376

8.  Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1.

Authors:  Cyril Jacquot; Sheng Peng; Wilfred A van der Donk
Journal:  Bioorg Med Chem Lett       Date:  2008-08-31       Impact factor: 2.823

9.  Mass-spectrometric characterization of phospholipids and their primary peroxidation products in rat cortical neurons during staurosporine-induced apoptosis.

Authors:  Vladimir A Tyurin; Yulia Y Tyurina; Weihong Feng; Alexandra Mnuskin; Jianfei Jiang; Minke Tang; Xiaojing Zhang; Qing Zhao; Patrick M Kochanek; Robert S B Clark; Hülya Bayir; Valerian E Kagan
Journal:  J Neurochem       Date:  2008-11-06       Impact factor: 5.372

10.  A Revised Mechanism for Human Cyclooxygenase-2.

Authors:  Yi Liu; Justine P Roth
Journal:  J Biol Chem       Date:  2015-11-12       Impact factor: 5.157
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