Literature DB >> 14677935

Design of a cyclic peptide that targets a viral RNA.

Steven T Runyon1, Joseph D Puglisi.   

Abstract

The Tat protein controls transcription in lentiviruses such as HIV. A cyclic peptide analog of the RNA binding domain of the bovine immunodeficiency virus (BIV) Tat protein is shown to bind specifically to its target RNA stem loop. NMR data indicate a similar mode of binding of linear and cyclic peptides.

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Year:  2003        PMID: 14677935     DOI: 10.1021/ja036344h

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN: 0002-7863            Impact factor:   15.419


  6 in total

1.  Targeting RNA with cysteine-constrained peptides.

Authors:  Virginia A Burns; Benjamin G Bobay; Anne Basso; John Cavanagh; Christian Melander
Journal:  Bioorg Med Chem Lett       Date:  2007-11-28       Impact factor: 2.823

2.  An alpha-helical peptidomimetic inhibitor of the HIV-1 Rev-RRE interaction.

Authors:  Nicholas L Mills; Matthew D Daugherty; Alan D Frankel; R Kiplin Guy
Journal:  J Am Chem Soc       Date:  2006-03-22       Impact factor: 15.419

3.  A single intermolecular contact mediates intramolecular stabilization of both RNA and protein.

Authors:  Valerie Calabro; Matthew D Daugherty; Alan D Frankel
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-27       Impact factor: 11.205

Review 4.  RNA-Binding Macrocyclic Peptides.

Authors:  Sunit Pal; Peter 't Hart
Journal:  Front Mol Biosci       Date:  2022-04-19

5.  Recognition of RNA duplexes by chemically modified triplex-forming oligonucleotides.

Authors:  Yuan Zhou; Elzbieta Kierzek; Zi Ping Loo; Meraldo Antonio; Yin Hoe Yau; York Wieo Chuah; Susana Geifman-Shochat; Ryszard Kierzek; Gang Chen
Journal:  Nucleic Acids Res       Date:  2013-05-08       Impact factor: 16.971

6.  The Effects of Charged Amino Acid Side-Chain Length on Diagonal Cross-Strand Interactions between Carboxylate- and Ammonium-Containing Residues in a β-Hairpin.

Authors:  Jing-Yuan Chang; Yen-Jin Pan; Pei-Yu Huang; Yi-Ting Sun; Chen-Hsu Yu; Zhi-Jun Ning; Shou-Ling Huang; Shing-Jong Huang; Richard P Cheng
Journal:  Molecules       Date:  2022-06-29       Impact factor: 4.927

  6 in total

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