Literature DB >> 14677933

Ageladine A: an antiangiogenic matrixmetalloproteinase inhibitor from the marine sponge Agelas nakamurai.

Masaki Fujita1, Yoichi Nakao, Shigeki Matsunaga, Motoharu Seiki, Yoshifumi Itoh, Jun Yamashita, Rob W M Van Soest, Nobuhiro Fusetani.   

Abstract

A novel MMP inhibitor, ageladine A (1) with antiangiogenic activity was isolated from a marine sponge Agelas nakamurai. Structure 1 was determined by a combination of spectroscopic and chemical methods to be an unprecedented structure of 4-(4,5-dibromo-1H-pyrrol-2-yl)]-1H-imidazo[4,5-c]pyridin-2-amine.

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Year:  2003        PMID: 14677933     DOI: 10.1021/ja038025w

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN: 0002-7863            Impact factor:   15.419


  21 in total

Review 1.  Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2007-02-09       Impact factor: 3.228

Review 2.  Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids.

Authors:  Ali Al-Mourabit; Manuel A Zancanella; Supriya Tilvi; Daniel Romo
Journal:  Nat Prod Rep       Date:  2011-05-09       Impact factor: 13.423

3.  Inhibitory effect of chitooligosaccharides on matrix metalloproteinase-9 in human fibrosarcoma cells (HT1080).

Authors:  Quang Van Ta; Moon-Moo Kim; Se-Kwon Kim
Journal:  Mar Biotechnol (NY)       Date:  2006-11-08       Impact factor: 3.619

Review 4.  Matrix metalloproteinase inhibitors (MMPIs) from marine natural products: the current situation and future prospects.

Authors:  Chen Zhang; Se-Kwon Kim
Journal:  Mar Drugs       Date:  2009-03-31       Impact factor: 5.118

5.  Synthesis and anticancer activities of ageladine A and structural analogs.

Authors:  Yuelong Ma; Sangkil Nam; Richard Jove; Kenichi Yakushijin; David A Horne
Journal:  Bioorg Med Chem Lett       Date:  2009-11-14       Impact factor: 2.823

Review 6.  Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer's Disease.

Authors:  Lidia Ciccone; Jennifer Vandooren; Susanna Nencetti; Elisabetta Orlandini
Journal:  Pharmaceuticals (Basel)       Date:  2021-01-24

7.  Metalloproteinase inhibitors: status and scope from marine organisms.

Authors:  Noel Vinay Thomas; Se-Kwon Kim
Journal:  Biochem Res Int       Date:  2010-12-09

8.  The alkaloid Ageladine A, originally isolated from marine sponges, used for pH-sensitive imaging of transparent marine animals.

Authors:  Ulf Bickmeyer
Journal:  Mar Drugs       Date:  2012-01-19       Impact factor: 6.085

9.  The chemically synthesized ageladine A-derivative LysoGlow84 stains lysosomes in viable mammalian brain cells and specific structures in the marine flatworm Macrostomum lignano.

Authors:  Thorsten Mordhorst; Sushil Awal; Sebastian Jordan; Charlotte Petters; Linda Sartoris; Ralf Dringen; Ulf Bickmeyer
Journal:  Mar Drugs       Date:  2015-02-11       Impact factor: 5.118

Review 10.  A submarine journey: the pyrrole-imidazole alkaloids.

Authors:  Barbara Forte; Beatrice Malgesini; Claudia Piutti; Francesca Quartieri; Alessandra Scolaro; Gianluca Papeo
Journal:  Mar Drugs       Date:  2009-11-27       Impact factor: 5.118

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