Literature DB >> 33498927

Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer's Disease.

Lidia Ciccone1, Jennifer Vandooren2, Susanna Nencetti1,3, Elisabetta Orlandini4,5.   

Abstract

Several studies have reported neuroprotective effects by natural products. A wide range of natural compounds have been investigated, and some of these may play a beneficial role in Alzheimer's disease (AD) progression. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, have been implicated in AD. In particular, MMP-2 and MMP-9 are able to trigger several neuroinflammatory and neurodegenerative pathways. In this review, we summarize and discuss existing literature on natural marine and terrestrial compounds, as well as their ability to modulate MMP-2 and MMP-9, and we evaluate their potential as therapeutic compounds for neurodegenerative and neuroinflammatory diseases, with a focus on Alzheimer's disease.

Entities:  

Keywords:  AD; Alzheimer’s disease; MMP-2; MMP-9; marine compounds; natural compounds; neurodegeneration; neuroinflammation; nutraceuticals; terrestrial compounds

Year:  2021        PMID： 33498927      PMCID： PMC7911533          DOI： 10.3390/ph14020086

Source DB:  PubMed          Journal:  Pharmaceuticals (Basel)        ISSN： 1424-8247


  155 in total

1.  Naringin suppresses cell metastasis and the expression of matrix metalloproteinases (MMP-2 and MMP-9) via the inhibition of ERK-P38-JNK signaling pathway in human glioblastoma.

Authors:  Sonia Aroui; Bakhta Aouey; Yassine Chtourou; Annie-Claire Meunier; Hamadi Fetoui; Abderraouf Kenani
Journal:  Chem Biol Interact       Date:  2015-12-22       Impact factor: 5.192

2.  Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain.

Authors:  Jennifer Vandooren; Nathalie Geurts; Erik Martens; Philippe E Van den Steen; Steven De Jonghe; Piet Herdewijn; Ghislain Opdenakker
Journal:  World J Biol Chem       Date:  2011-01-26

Review 3.  Zymography methods for visualizing hydrolytic enzymes.

Authors:  Jennifer Vandooren; Nathalie Geurts; Erik Martens; Philippe E Van den Steen; Ghislain Opdenakker
Journal:  Nat Methods       Date:  2013-03       Impact factor: 28.547

Review 4.  Alzheimer's disease: Recent treatment strategies.

Authors:  Miguel Vaz; Samuel Silvestre
Journal:  Eur J Pharmacol       Date:  2020-09-15       Impact factor: 4.432

5.  Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice.

Authors:  Ashfaq Ahmad; Tahir Ali; Hyun Young Park; Haroon Badshah; Shafiq Ur Rehman; Myeong Ok Kim
Journal:  Mol Neurobiol       Date:  2016-03-05       Impact factor: 5.590

6.  Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events.

Authors:  Linda J Noble; Frances Donovan; Takuji Igarashi; Staci Goussev; Zena Werb
Journal:  J Neurosci       Date:  2002-09-01       Impact factor: 6.167

7.  Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by down-regulating MMP2 and MMP9.

Authors:  Huidi Liu; Zheng Zeng; Siwen Wang; Ting Li; Emilio Mastriani; Qing-Hai Li; Hong-Xia Bao; Yu-Jie Zhou; Xiaoyu Wang; Yongfang Liu; Wei Liu; Sijing Hu; Shan Gao; Miao Yu; Yingying Qi; Zhihang Shen; Hongyue Wang; Tingting Gao; Lingqin Dong; Randal N Johnston; Shu-Lin Liu
Journal:  Cancer Biol Ther       Date:  2017-11-27       Impact factor: 4.742

Review 8.  Molecular Mechanisms of Anticancer Activities of Puerarin.

Authors:  Bashir Ahmad; Suliman Khan; Yang Liu; Mengzhou Xue; Ghulam Nabi; Sunjeet Kumar; Mohammed Alshwmi; Abdul Wakeel Qarluq
Journal:  Cancer Manag Res       Date:  2020-01-08       Impact factor: 3.989

9.  Sinulariolide Suppresses Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase through the PI3K/AKT/mTOR Signaling Pathway in Human Bladder Cancer Cells.

Authors:  Te-Chih Cheng; Zhong-Hao Din; Jui-Hsin Su; Yu-Jen Wu; Chih-I Liu
Journal:  Mar Drugs       Date:  2017-08-02       Impact factor: 5.118

Review 10.  Natural compounds as inhibitors of transthyretin amyloidosis and neuroprotective agents: analysis of structural data for future drug design.

Authors:  Lidia Ciccone; Nicoló Tonali; Susanna Nencetti; Elisabetta Orlandini
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
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  6 in total

Review 1.  Matrix metalloproteinase contribution in management of cancer proliferation, metastasis and drug targeting.

Authors:  Nabil M Abdel-Hamid; Shimaa A Abass
Journal:  Mol Biol Rep       Date:  2021-08-11       Impact factor: 2.316

2.  Pterostilbene fluorescent probes as potential tools for targeting neurodegeneration in biological applications.

Authors:  Lidia Ciccone; Susanna Nencetti; Maria Marino; Chiara Battocchio; Giovanna Iucci; Iole Venditti; Martina Marsotto; Emiliano Montalesi; Simone Socci; Beatrice Bargagna; Elisabetta Orlandini
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

3.  Nano-PSO Administration Attenuates Cognitive and Neuronal Deficits Resulting from Traumatic Brain Injury.

Authors:  Doaa Qubty; Kati Frid; Meirav Har-Even; Vardit Rubovitch; Ruth Gabizon; Chaim G Pick
Journal:  Molecules       Date:  2022-04-23       Impact factor: 4.927

4.  Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice.

Authors:  Yu-Young Lee; Ming Wang; Yurim Son; Eun-Ju Yang; Moon-Seok Kang; Hyun-Joo Kim; Hyung-Seok Kim; Jihoon Jo
Journal:  Molecules       Date:  2021-10-10       Impact factor: 4.411

Review 5.  The Role of Extracellular Matrix in Human Neurodegenerative Diseases.

Authors:  Panka Pintér; Alán Alpár
Journal:  Int J Mol Sci       Date:  2022-09-21       Impact factor: 6.208

Review 6.  Exploitation of Marine Molecules to Manage Alzheimer's Disease.

Authors:  Marisa Silva; Paula Seijas; Paz Otero
Journal:  Mar Drugs       Date:  2021-06-28       Impact factor: 5.118
  6 in total

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