BACKGROUND: Fagara zanthoxyloides is a well known medicinal plant in Uganda. It is used extensively in malaria and other infections. However nothing is known about its toxicity. OBJECTIVE: The objective of the study was to evaluate the acute toxicity of the methanolic extract of the root-bark of F. zanthoxyloides, in mice. METHODS: Methanolic extract of the root-bark of the plant was administered orally to mice at various dose levels to determine the acute toxic effects and the median lethal dose (LD50) in mice. RESULTS: The LD50 of the methanolic extract was found to be 5.0 g/Kg body weight within 95% confidence limits. The mice showed signs of cerebral irritation before dying. Histopathological examinations of the viscera showed congestion and focal necrosis of the liver and renal tubules. CONCLUSION: It was concluded that the extract of F. zanthoxyloides is safe, however the cerebral mechanism that lead to the death of the mice need to be investigated further.
BACKGROUND: Fagara zanthoxyloides is a well known medicinal plant in Uganda. It is used extensively in malaria and other infections. However nothing is known about its toxicity. OBJECTIVE: The objective of the study was to evaluate the acute toxicity of the methanolic extract of the root-bark of F. zanthoxyloides, in mice. METHODS:Methanolic extract of the root-bark of the plant was administered orally to mice at various dose levels to determine the acute toxic effects and the median lethal dose (LD50) in mice. RESULTS: The LD50 of the methanolic extract was found to be 5.0 g/Kg body weight within 95% confidence limits. The mice showed signs of cerebral irritation before dying. Histopathological examinations of the viscera showed congestion and focal necrosis of the liver and renal tubules. CONCLUSION: It was concluded that the extract of F. zanthoxyloides is safe, however the cerebral mechanism that lead to the death of the mice need to be investigated further.
Authors: Olakunle O Kassim; Mark Loyevsky; Biaffra Elliott; Andrew Geall; Henrietta Amonoo; Victor R Gordeuk Journal: Antimicrob Agents Chemother Date: 2005-01 Impact factor: 5.191
Authors: Comlan de Souza; Yaovi Ameyapoh; Simplice D Karou; Kokou T Anani; Madje L Kpodar; Mensavi Gbeassor Journal: Biotechnol Res Int Date: 2010-08-24
Authors: Patrick Valere Tsouh Fokou; Alexander Kwadwo Nyarko; Regina Appiah-Opong; Lauve Rachel Tchokouaha Yamthe; Mark Ofosuhene; Fabrice Fekam Boyom Journal: Biomed Res Int Date: 2015-12-08 Impact factor: 3.411