Literature DB >> 14675759

Properties of the co-chaperone protein p23 erroneously attributed to ALG-2 (apoptosis-linked gene 2).

Jens Mollerup1, Thomas N Krogh, Per F Nielsen, Martin W Berchtold.   

Abstract

A commercial antibody (clone 22) directed against the apoptosis-linked gene 2 (alg2, pdcd6) encoded protein has been used by several groups. Up-regulated expression of the antigen was observed in primary tumours and in metastatic tissue and also during rat brain ischemia. Furthermore, antigen down-regulation was found in human atherosclerotic plaques. Recently, we found that the clone 22 antibody does not recognise ALG-2. In the present study the antigen of the clone 22 antibody was identified as the heat shock protein 90 (HSP90) co-chaperone protein p23, identical to the cytosolic prostaglandin E2 synthase, by immunoprecipitation followed by tryptic in-gel digests and mass spectrometry of the purified peptides. Moreover, the heterogeneous ribonuclear protein A2/B1 was found to be a part of the p23 co-immunoprecipitated protein complex.

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Year:  2003        PMID： 14675759     DOI： 10.1016/s0014-5793(03)01310-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion.

Authors:  Ellinor Oxelmark; Jennifer M Roth; Peter C Brooks; Steven E Braunstein; Robert J Schneider; Michael J Garabedian
Journal:  Mol Cell Biol       Date:  2006-07       Impact factor: 4.272

2.  High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance.

Authors:  Natalie E Simpson; W Marcus Lambert; Renecia Watkins; Shah Giashuddin; S Joseph Huang; Ellinor Oxelmark; Rezina Arju; Tsivia Hochman; Judith D Goldberg; Robert J Schneider; Luiz Fernando Lima Reiz; Fernando Augusto Soares; Susan K Logan; Michael J Garabedian
Journal:  Cancer Res       Date:  2010-09-16       Impact factor: 12.701

3.  The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability.

Authors:  Jonas M la Cour; Berit R Høj; Jens Mollerup; Ronald Simon; Guido Sauter; Martin W Berchtold
Journal:  Mol Oncol       Date:  2007-08-19       Impact factor: 6.603

4.  p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity.

Authors:  Fedor Forafonov; Oyetunji A Toogun; Iwona Grad; Elena Suslova; Brian C Freeman; Didier Picard
Journal:  Mol Cell Biol       Date:  2008-03-24       Impact factor: 4.272

5.  Variations in the PDCD6 gene are associated with increased uterine leiomyoma risk in the Chinese.

Authors:  Kui Zhang; Bin Zhou; Shaoqing Shi; Yaping Song; Lin Zhang
Journal:  Genet Test Mol Biomarkers       Date:  2013-04-03

6.  Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma.

Authors:  Lalita Subramanian; John W Crabb; Jos Cox; Isabelle Durussel; Teresa M Walker; Paul R van Ginkel; Saswati Bhattacharya; Julia M Dellaria; Krzysztof Palczewski; Arthur S Polans
Journal:  Biochemistry       Date:  2004-09-07       Impact factor: 3.162

Review 7.  Epigenetic Alterations of Heat Shock Proteins (HSPs) in Cancer.

Authors:  Hyun Seung Ban; Tae-Su Han; Keun Hur; Hyun-Soo Cho
Journal:  Int J Mol Sci       Date:  2019-09-25       Impact factor: 5.923

8.  Role of the HSP90-associated cochaperone p23 in enhancing activity of the androgen receptor and significance for prostate cancer.

Authors:  Vikash Reebye; Laia Querol Cano; Derek N Lavery; Greg N Brooke; Sue M Powell; Deepa Chotai; Marjorie M Walker; Hayley C Whitaker; Robin Wait; Helen C Hurst; Charlotte L Bevan
Journal:  Mol Endocrinol       Date:  2012-08-16

Review 9.  Multifaceted Roles of ALG-2 in Ca(2+)-Regulated Membrane Trafficking.

Authors:  Masatoshi Maki; Terunao Takahara; Hideki Shibata
Journal:  Int J Mol Sci       Date:  2016-08-26       Impact factor: 5.923

10.  The co-chaperone p23 promotes prostate cancer motility and metastasis.

Authors:  Laia Querol Cano; Derek N Lavery; Soraya Sin; Emma Spanjaard; Greg N Brooke; Jessica D Tilman; Ahmed Abroaf; Luke Gaughan; Craig N Robson; Rakesh Heer; Francesco Mauri; Johan de Rooij; Keltouma Driouch; Charlotte L Bevan
Journal:  Mol Oncol       Date:  2014-09-06       Impact factor: 6.603
  10 in total

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