| Literature DB >> 14675596 |
Julian F Thayer1, Marcellus M Merritt, John J Sollers, Alan B Zonderman, Michele K Evans, Sue Yie, Darrell R Abernethy.
Abstract
Seventy-nine African-American participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) pilot study were genotyped for the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and had spectral power of their high-frequency (HF) heart rate variability (HRV) determined by fast-Fourier transformation. HF HRV was highest in II, intermediate in ID, and lowest in DD (II vs DD, p <0.043) genotypes, thus making an association of the ACE I/D DD genotype with decreased HF HRV that is consistent with the hypothesis that the DD genotype confers susceptibility to increased cardiovascular risk. The urban African-American population we studied had a particularly high cardiovascular risk, and these findings suggest that ACE I/D genotypes may modify that risk.Entities:
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Year: 2003 PMID： 14675596 DOI： 10.1016/j.amjcard.2003.08.069
Source DB: PubMed Journal: Am J Cardiol ISSN： 0002-9149 Impact factor: 2.778