Literature DB >> 14675542

Mycobacterium tuberculosis: a model system for structural genomics.

Clare V Smith1, James C Sacchettini.   

Abstract

Over the past five years, genomics has had a major impact on Mycobacterium tuberculosis research. With the publication of the sequences of two virulent strains (H37Rv and CDC1551) and three closely related sequences, M. tuberculosis is becoming a model system for proteomics and structural genomics initiatives. Together with the promise of structures of proteins with novel folds, high-resolution structures of drug targets are providing the basis for rational inhibitor design, with the goal of the development of novel anti-tuberculars. In addition, this work is aiding scientists in the quest for an effective vaccine against this persistent pathogen.

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Year:  2003        PMID： 14675542     DOI： 10.1016/j.sbi.2003.10.004

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  9 in total

1.  Structural genomics of eukaryotic targets at a laboratory scale.

Authors:  Didier Busso; Pierre Poussin-Courmontagne; David Rosé; Raymond Ripp; Alain Litt; Jean-Claude Thierry; Dino Moras
Journal:  J Struct Funct Genomics       Date:  2005

2.  Cloning, expression, purification, crystallization and preliminary X-ray studies of epoxide hydrolases A and B from Mycobacterium tuberculosis.

Authors:  Bichitra K Biswal; Grace Garen; Maia M Cherney; Craig Garen; Michael N G James
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-01-27

3.  Expression, purification and preliminary X-ray analysis of the C-terminal domain of an arginine repressor protein from Mycobacterium tuberculosis.

Authors:  George J Lu; Craig R Garen; Maia M Cherney; Leonid T Cherney; Cecilia Lee; Michael N G James
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2007-10-24

4.  Preliminary X-ray crystallographic analysis of ornithine acetyltransferase (Rv1653) from Mycobacterium tuberculosis.

Authors:  R Sankaranarayanan; C R Garen; M M Cherney; M Yuan; C Lee; M N G James
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-01-31

5.  Expression, purification and preliminary crystallographic analysis of N-acetylglucosamine-1-phosphate uridylyltransferase from Mycobacterium tuberculosis.

Authors:  Jiang Yin; Craig R Garen; Maia M Cherney; Leonid T Cherney; Michael N G James
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-08-09

6.  Expression, purification, crystallization and preliminary X-ray analysis of two arginine-biosynthetic enzymes from Mycobacterium tuberculosis.

Authors:  Fatemeh Moradian; Craig Garen; Leonid Cherney; Maia Cherney; Michael N G James
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-09-30

7.  The molecular structure of Rv2074, a probable pyridoxine 5'-phosphate oxidase from Mycobacterium tuberculosis, at 1.6 angstroms resolution.

Authors:  Bichitra K Biswal; Karolyn Au; Maia M Cherney; Craig Garen; Michael N G James
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-07-24

8.  Expression, purification and preliminary crystallographic analysis of O-acetylhomoserine sulfhydrylase from Mycobacterium tuberculosis.

Authors:  Jiang Yin; Craig R Garen; Katherine Bateman; Minmin Yu; Emily Z Alipio Lyon; Jeff Habel; Heungbok Kim; Li-wei Hung; Chang-Yub Kim; Michael N G James
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-07-27

9.  Can an infectious disease genomics project predict and prevent the next pandemic?

Authors:  Rajesh Gupta; Mark H Michalski; Frank R Rijsberman
Journal:  PLoS Biol       Date:  2009-10-26       Impact factor: 8.029
  9 in total

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