| Literature DB >> 14671644 |
U Testa1, R Riccioni, D Diverio, A Rossini, F Lo Coco, C Peschle.
Abstract
Recent studies indicate that abnormalities of the interleukin-3 receptor (IL-3R) are frequently observed in acute myeloid leukemias (AMLs) and may contribute to the proliferative advantage of leukemic blasts. This review analyzes the evidences indicating that the IL-3R represents one of the target molecules involved in the stimulation of proliferation of AMLs, and the overexpression of the IL-3Ralpha chain may represent one of the mechanisms contributing to the development of a highly malignant leukemic phenotype. Furthermore, there is evidence that the IL-3Ralpha is a marker of leukemic stem cells, at variance with normal stem cells that are IL-3Ralpha-. Finally, the IL-3R may represent an important target for the development of new antileukemic drugs.Entities:
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Year: 2004 PMID： 14671644 DOI： 10.1038/sj.leu.2403224
Source DB: PubMed Journal: Leukemia ISSN： 0887-6924 Impact factor: 11.528