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Literature DB >> 1467140

Morphine metabolism in neonates and infants.

I Choonara¹, A Lawrence, A Michalkiewicz, A Bowhay, J Ratcliffe.

Abstract

The metabolism of morphine was studied in seven fullterm neonates and five infants receiving a continuous infusion of morphine. All the patients had detectable plasma concentrations of morphine 3-glucuronide (M3G) and 10 had detectable concentrations of morphine 6-glucuronide (M6G). The mean plasma clearance of morphine was 20.1 ml min-1 kg-1 in neonates and 23.4 ml min-1 kg-1 in the group as a whole. The M3G/morphine ratio (7.3) was higher than that previously reported for preterm neonates (5.0) but lower than that reported for children (23.9).

Entities: Chemical Gene Species

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Year: 1992 PMID： 1467140 PMCID： PMC1381474 DOI： 10.1111/j.1365-2125.1992.tb05652.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

17 in total

Review 1. Management of pain in newborn infants.

Authors: I Choonara
Journal: Semin Perinatol Date: 1992-02 Impact factor: 3.300

2. The metabolism and bioavailability of morphine in patients with severe liver cirrhosis.

Authors: J Hasselström; S Eriksson; A Persson; A Rane; J O Svensson; J Säwe
Journal: Br J Clin Pharmacol Date: 1990-03 Impact factor: 4.335

3. Fast reliable assay for morphine and its metabolites using high-performance liquid chromatography and native fluorescence detection.

Authors: R F Venn; A Michalkiewicz
Journal: J Chromatogr Date: 1990-02-23

4. Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuronide.

Authors: Q L Gong; T Hedner; J Hedner; R Björkman; G Nordberg
Journal: Eur J Pharmacol Date: 1991-01-25 Impact factor: 4.432

5. Analgesic effect of morphine glucuronides.

Authors: K Shimomura; O Kamata; S Ueki; S Ida; K Oguri; H Yoshimura; H Tsukamoto
Journal: Tohoku J Exp Med Date: 1971-09 Impact factor: 1.848

6. Analgesic activity of morphine-6-glucuronide.

Authors: R Osborne; S Joel; D Trew; M Slevin
Journal: Lancet Date: 1988-04-09 Impact factor: 79.321

7. Morphine metabolism in children.

Authors: I A Choonara; P McKay; R Hain; A Rane
Journal: Br J Clin Pharmacol Date: 1989-11 Impact factor: 4.335

8. Morphine metabolism in cancer patients on increasing oral doses--no evidence for autoinduction or dose-dependence.

Authors: J Säwe; J O Svensson; A Rane
Journal: Br J Clin Pharmacol Date: 1983-07 Impact factor: 4.335

9. Morphine pharmacokinetics in early infancy.

Authors: A M Lynn; J T Slattery
Journal: Anesthesiology Date: 1987-02 Impact factor: 7.892

10. In vitro evidence for the involvement of at least two forms of human liver UDP-glucuronosyltransferase in morphine 3-glucuronidation.

Authors: J O Miners; K J Lillywhite; D J Birkett
Journal: Biochem Pharmacol Date: 1988-07-15 Impact factor: 5.858

20 in total

1. Morphine induced allodynia in a child with brain tumour.

Authors: S Heger; C Maier; K Otter; U Helwig; M Suttorp
Journal: BMJ Date: 1999-09-04

2. Morphine induced allodynia in child with brain tumour. Signs are more likely to have been due to underlying medical condition.

Authors: I L Marples; P Murray
Journal: BMJ Date: 2000-02-05

10. Pharmacodynamic Analysis of Morphine Time-to-Remedication Events in Infants and Young Children After Congenital Heart Surgery.

Authors: Mohammed H Elkomy; David R Drover; Jeffery L Galinkin; Gregory B Hammer; Kristi L Glotzbach
Journal: Clin Pharmacokinet Date: 2016-10 Impact factor: 6.447

Morphine metabolism in neonates and infants.

Review 1. Management of pain in newborn infants.

2. The metabolism and bioavailability of morphine in patients with severe liver cirrhosis.

3. Fast reliable assay for morphine and its metabolites using high-performance liquid chromatography and native fluorescence detection.

4. Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuronide.

5. Analgesic effect of morphine glucuronides.

6. Analgesic activity of morphine-6-glucuronide.

7. Morphine metabolism in children.

8. Morphine metabolism in cancer patients on increasing oral doses--no evidence for autoinduction or dose-dependence.

9. Morphine pharmacokinetics in early infancy.

10. In vitro evidence for the involvement of at least two forms of human liver UDP-glucuronosyltransferase in morphine 3-glucuronidation.

1. Morphine induced allodynia in a child with brain tumour.

2. Morphine induced allodynia in child with brain tumour. Signs are more likely to have been due to underlying medical condition.

Review 3. Drug trials in children: problems and the way forward.

Review 4. Strong opioids in pediatric palliative medicine.

Review 5. Clinical pharmacokinetics of sedatives in neonates.

6. Paradoxical pain.

7. Morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of children.

Review 8. Treating Chronic Pain: An Overview of Clinical Studies Centered on the Buprenorphine Option.

Review 9. Clinical pharmacokinetics and pharmacodynamics of opioid analgesics in infants and children.

10. Pharmacodynamic Analysis of Morphine Time-to-Remedication Events in Infants and Young Children After Congenital Heart Surgery.