Literature DB >> 14671315

Reversing cerebellar long-term depression.

Varda Lev-Ram1, Samar B Mehta, David Kleinfeld, Roger Y Tsien.   

Abstract

The discovery of a postsynaptically expressed form of cerebellar parallel fiber-Purkinje cell long-term potentiation (LTP) raises the question whether this is the long-sought resetting mechanism for long-term depression (LTD). Extracellular monitoring of PC spikes enables stable prolonged recordings of parallel fiber-Purkinje cell synaptic efficacy. LTD, saturated by repeated induction protocols, can be reversed by a single round of postsynaptic LTP or nitric oxide (NO), enabling LTD to be reinduced. Conversely, after postsynaptic LTP has been saturated, one round of LTD permits fresh postsynaptic LTP. By contrast, after saturation of LTD, induction of presynaptic LTP or application of forskolin leaves LTD still saturated. Likewise, presynaptic LTP cannot be reversed by LTD. Therefore postsynaptic LTP mediated by NO without postsynaptic Ca2+ elevation, unlike presynaptic LTP mediated by cAMP, is a true counterbalance to LTD mediated by coincidence of NO plus postsynaptic Ca2+

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Year:  2003        PMID： 14671315      PMCID： PMC307680          DOI： 10.1073/pnas.2636935100

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

Review 1.  Mechanisms of cerebellar learning suggested by eyelid conditioning.

Authors:  J F Medina; W L Nores; T Ohyama; M D Mauk
Journal:  Curr Opin Neurobiol       Date:  2000-12       Impact factor: 6.627

2.  Reversible associative depression and nonassociative potentiation at a parallel fiber synapse.

Authors:  V Z Han; K Grant; C C Bell
Journal:  Neuron       Date:  2000-09       Impact factor: 17.173

3.  Quantification of spread of cerebellar long-term depression with chemical two-photon uncaging of glutamate.

Authors:  S S Wang; L Khiroug; G J Augustine
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-18       Impact factor: 11.205

4.  Inhibition of climbing fibres is a signal for the extinction of conditioned eyelid responses.

Authors:  Javier F Medina; William L Nores; Michael D Mauk
Journal:  Nature       Date:  2002-03-21       Impact factor: 49.962

5.  A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP.

Authors:  Varda Lev-Ram; Scott T Wong; Daniel R Storm; Roger Y Tsien
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-04       Impact factor: 11.205

6.  Reciprocal bidirectional plasticity of parallel fiber receptive fields in cerebellar Purkinje cells and their afferent interneurons.

Authors:  Henrik Jörntell; Carl-Fredrik Ekerot
Journal:  Neuron       Date:  2002-05-30       Impact factor: 17.173

7.  Absence of cerebellar long-term depression in mice lacking neuronal nitric oxide synthase.

Authors:  V Lev-Ram; Z Nebyelul; M H Ellisman; P L Huang; R Y Tsien
Journal:  Learn Mem       Date:  1997 May-Jun       Impact factor: 2.460

8.  Activation of presynaptic cAMP-dependent protein kinase is required for induction of cerebellar long-term potentiation.

Authors:  D J Linden; S Ahn
Journal:  J Neurosci       Date:  1999-12-01       Impact factor: 6.167

Review 9.  Cerebellar long-term depression: characterization, signal transduction, and functional roles.

Authors:  M Ito
Journal:  Physiol Rev       Date:  2001-07       Impact factor: 37.312

10.  Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse.

Authors:  M Casado; S Dieudonné; P Ascher
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-10       Impact factor: 11.205
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  51 in total

1.  Extinction as new learning versus unlearning: considerations from a computer simulation of the cerebellum.

Authors:  Michael D Mauk; Tatsuya Ohyama
Journal:  Learn Mem       Date:  2004 Sep-Oct       Impact factor: 2.460

2.  Temporal patterns of inputs to cerebellum necessary and sufficient for trace eyelid conditioning.

Authors:  Brian E Kalmbach; Tatsuya Ohyama; Michael D Mauk
Journal:  J Neurophysiol       Date:  2010-05-19       Impact factor: 2.714

3.  Lock-and-key mechanisms of cerebellar memory recall based on rebound currents.

Authors:  Daniel Z Wetmore; Eran A Mukamel; Mark J Schnitzer
Journal:  J Neurophysiol       Date:  2007-08-01       Impact factor: 2.714

4.  A mechanism underlying AMPA receptor trafficking during cerebellar long-term potentiation.

Authors:  Wataru Kakegawa; Michisuke Yuzaki
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-22       Impact factor: 11.205

5.  Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit.

Authors:  Spencer Lavere Smith; Thomas Stephen Otis
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-30       Impact factor: 11.205

6.  Linking synaptic plasticity and spike output at excitatory and inhibitory synapses onto cerebellar Purkinje cells.

Authors:  Wolfgang Mittmann; Michael Häusser
Journal:  J Neurosci       Date:  2007-05-23       Impact factor: 6.167

7.  Learning-related long-term potentiation of inhibitory synapses in the cerebellar cortex.

Authors:  Bibiana Scelfo; Benedetto Sacchetti; Piergiorgio Strata
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-09       Impact factor: 11.205

8.  Presynaptically expressed long-term depression at cerebellar parallel fiber synapses.

Authors:  De-lai Qiu; Thomas Knöpfel
Journal:  Pflugers Arch       Date:  2008-07-29       Impact factor: 3.657

Review 9.  The cerebellum, cerebellar disorders, and cerebellar research--two centuries of discoveries.

Authors:  Mario Manto
Journal:  Cerebellum       Date:  2008       Impact factor: 3.847

10.  CO(2) signaling in guard cells: calcium sensitivity response modulation, a Ca(2+)-independent phase, and CO(2) insensitivity of the gca2 mutant.

Authors:  Jared J Young; Samar Mehta; Maria Israelsson; Jan Godoski; Erwin Grill; Julian I Schroeder
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-01       Impact factor: 11.205
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