Literature DB >> 14670768

Herbal creams used for atopic eczema in Birmingham, UK illegally contain potent corticosteroids.

H M Ramsay1, W Goddard, S Gill, C Moss.   

Abstract

AIMS: To determine whether "herbal creams" reported as being effective for the treatment of childhood atopic eczema contained corticosteroids.
METHODS: Patients attending the paediatric dermatology clinic at Birmingham Children's Hospital, April 2001 to March 2002, and who reported using "herbal creams" with good effect for atopic eczema were asked to submit the cream for analysis. Hydrocortisone, clobetasone butyrate, betamethasone valerate, and clobetasol propionate were analysed by HPLC.
RESULTS: Twenty four creams from 19 patients, median (interquartile range) age 3.82 (0.69-7.98) years were analysed. All five creams labelled Wau Wa and the two labelled Muijiza cream contained clobetasol propionate. Thirteen of 17 unnamed creams contained corticosteroids: clobetasol proprionate (n = 4), clobetasol proprionate + hydrocortisone (n = 1), betamethasone valerate (n = 2), clobetasone butyrate (n = 3), and hydrocortisone (n = 2); there was an unidentified peak in one. Further analysis suggested Wau Wa cream contained approximately 20% proprietary Dermovate Cream in a paraffin base. No parents were aware that the creams contained steroid.
CONCLUSIONS: The majority of herbal creams analysed illegally contained potent or very potent topical steroids. There is an urgent need for tighter regulation of herbal creams and for increased public education about the potential dangers of alternative therapies.

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Year:  2003        PMID: 14670768      PMCID: PMC1719403          DOI: 10.1136/adc.88.12.1056

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN: 0003-9888            Impact factor:   3.791


  13 in total

Review 1.  Adverse effects of herbal drugs in dermatology.

Authors:  E Ernst
Journal:  Br J Dermatol       Date:  2000-11       Impact factor: 9.302

2.  Use of Wau Wa in dermatitis patients.

Authors:  Justin Daniels; Debbie Shaw; David Atherton
Journal:  Lancet       Date:  2002-09-28       Impact factor: 79.321

3.  Potent topical steroid obtained from a Chinese herbalist.

Authors:  J O'Driscoll; A D Burden; T P Kingston
Journal:  Br J Dermatol       Date:  1992-11       Impact factor: 9.302

4.  Comparison of hypothalamus-pituitary-adrenal axis suppression from superpotent topical steroids by standard endocrine function testing and gas chromatographic mass spectrometry.

Authors:  W L Weston; P V Fennessey; J Morelli; H Schwab; J Mooney; C Samson; L Huff; L M Harrison; R Gotlin
Journal:  J Invest Dermatol       Date:  1988-04       Impact factor: 8.551

5.  Adrenal suppression following low-dose topical clobetasol propionate.

Authors:  E M Ohman; S Rogers; F O Meenan; T J McKenna
Journal:  J R Soc Med       Date:  1987-07       Impact factor: 5.344

6.  Hypothalamus-pituitary-adrenal axis suppression by superpotent topical steroids.

Authors:  P Walsh; J L Aeling; L Huff; W L Weston
Journal:  J Am Acad Dermatol       Date:  1993-09       Impact factor: 11.527

7.  Chinese herbal remedies may contain steroids.

Authors:  R A Graham-Brown; J F Bourke; G Bumphrey
Journal:  BMJ       Date:  1994-02-12

8.  Cushing's syndrome induced by topical steroids used for the treatment of non-bullous ichthyosiform erythroderma.

Authors:  M Borzyskowski; D B Grant; R S Wells
Journal:  Clin Exp Dermatol       Date:  1976-12       Impact factor: 3.470

9.  Superpotent topical steroid treatment of psoriasis vulgaris--clinical efficacy and adrenal function.

Authors:  H I Katz; N T Hien; S E Prawer; L I Mastbaum; J J Mooney; C R Samson
Journal:  J Am Acad Dermatol       Date:  1987-04       Impact factor: 11.527

10.  Adrenocortical response to adrenocorticotropic hormone in relation to duration of topical therapy and percutaneous absorption of hydrocortisone in children with dermatitis.

Authors:  M Turpeinen
Journal:  Eur J Pediatr       Date:  1989-08       Impact factor: 3.183

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  6 in total

1.  Regulating herbal medicines in the UK.

Authors:  Robin E Ferner; Keith Beard
Journal:  BMJ       Date:  2005-07-09

2.  Immunoglobulin e, interleukin-18 and interleukin-12 in patients with atopic dermatitis: correlation with disease activity.

Authors:  Khaled Zedan; Zafar Rasheed; Yaser Farouk; Abdullateef A Alzolibani; Ghada Bin Saif; Hisham A Ismail; Ahmad A Al Robaee
Journal:  J Clin Diagn Res       Date:  2015-04-01

3.  Paradoxical use of oral and topical steroids in steroid-phobic patients resorting to traditional Chinese medicines.

Authors:  Kam-Lun E Hon; Ting Fan Leung; Ho Chung Yau; Thomas Chan
Journal:  World J Pediatr       Date:  2012-08-12       Impact factor: 2.764

4.  A cross-sectional survey of complementary and alternative medicine use by children and adolescents attending the University Hospital of Wales.

Authors:  Nigel W Crawford; Domenic R Cincotta; Alissa Lim; Colin V E Powell
Journal:  BMC Complement Altern Med       Date:  2006-05-02       Impact factor: 3.659

5.  Application of LC-MS/MS for quantitative analysis of glucocorticoids and stimulants in biological fluids.

Authors:  Jamshed Haneef; Mohammad Shaharyar; Asif Husain; Mohd Rashid; Ravinesh Mishra; Shama Parveen; Niyaz Ahmed; Manoj Pal; Deepak Kumar
Journal:  J Pharm Anal       Date:  2013-04-02

6.  Systematic Evaluation of Corticosteroid Use in Obese and Non-obese Individuals: A Multi-cohort Study.

Authors:  Mesut Savas; Vincent L Wester; Sabine M Staufenbiel; Jan W Koper; Erica L T van den Akker; Jenny A Visser; Aart J van der Lely; Brenda W J H Penninx; Elisabeth F C van Rossum
Journal:  Int J Med Sci       Date:  2017-06-13       Impact factor: 3.738

  6 in total

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