Literature DB >> 146702

Regulation of isopropylmalate isomerase synthesis in Neurospora crassa.

V E Reichenbecher, M Fischer, S R Gross.   

Abstract

The capacity to synthetize isopropylmalate isomerase (EC 4.2.1.33) by Neurospora crassa increased during induction in the presence of cycloheximide but was inhibited by proflavine and other inhibitors of RNA synthesis. Turnover of the enzyme once formed appeared negligible, but the message (measured as enzyme-forming capacity) had a half-life of 4 to 8 min. A comparison of the kinetics of induction in the wild type and a newly isolated alpha-isopropylmalate-permeable strain suggested strongly that feedback control by leucine of alpha-isopropylmalate production can adequately serve as the primary physiological regulator of endogenous inducer concentration. Genetic data are presented which implicate the involvement of two unlinked genes, ipm-1 and ipm-2, in determining permeation of alpha-isopropylmalate.

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Year:  1978        PMID： 146702      PMCID： PMC222090          DOI： 10.1128/jb.133.2.794-801.1978

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  21 in total

1.  THE BIOSYNTHESIS OF LEUCINE. II. THE ENZYMIC ISOMERIZATION OF BETA-CARBOXY-BETA-HYDROXYISOCAPROATE AND ALPHA-HYDROXY-BETA-CARBOXYISOCAPROATE.

Authors:  S R GROSS; R O BURNS; H E UMBARGER
Journal:  Biochemistry       Date:  1963 Sep-Oct       Impact factor: 3.162

2.  KINETICS OF INDUCED ENZYME SYNTHESIS. DETERMINATION OF THE MEAN LIFE OF GALACTOSIDASE-SPECIFIC MESSENGER RNA.

Authors:  A KEPES
Journal:  Biochim Biophys Acta       Date:  1963-10-15

3.  Structural considerations in the interaction of DNA and acridines.

Authors:  L S LERMAN
Journal:  J Mol Biol       Date:  1961-02       Impact factor: 5.469

4.  A Plating Method for Genetic Analysis in Neurospora.

Authors:  D Newmeyer
Journal:  Genetics       Date:  1954-09       Impact factor: 4.562

Review 5.  Eukaryotic messenger RNA.

Authors:  G Brawerman
Journal:  Annu Rev Biochem       Date:  1974       Impact factor: 23.643

6.  Arginase induction in Aspergillus nidulans. The appearance and decay of the coding capacity of messenger.

Authors:  J Cybis; P Weglenski
Journal:  Eur J Biochem       Date:  1972-10

Review 7.  Control of enzyme levels in animal tissues.

Authors:  R T Schimke; D Doyle
Journal:  Annu Rev Biochem       Date:  1970       Impact factor: 23.643

8.  Transport of C 4 -dicarboxylic acids in Neurospora crassa.

Authors:  L Wolfinbarger; W W Kay
Journal:  Biochim Biophys Acta       Date:  1973-04-25

9.  Regulation of nitrate reductase in Neurospora crassa: regulation of transcription and translation.

Authors:  K N Subramanian; G J Sorger
Journal:  J Bacteriol       Date:  1972-05       Impact factor: 3.490

10.  Structural features of normal and complemented forms of the Neurospora isopropylmalate isomerase.

Authors:  V E Reichenbecher; S R Gross
Journal:  J Bacteriol       Date:  1978-02       Impact factor: 3.490
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  11 in total

1.  Nitrogen regulation of uricase synthesis in Neurospora crassa.

Authors:  L W Wang; G A Marzluf
Journal:  Mol Gen Genet       Date:  1979-11

2.  Leucine biosynthesis in yeast : Identification of two genes (LEU4, LEU5) that affect α-Isopropylmalate synthase activity and evidence that LEU1 and LEU2 gene expression is controlled by α-Isopropylmalate and the product of a regulatory gene.

Authors:  V R Baichwal; T S Cunningham; P R Gatzek; G B Kohlhaw
Journal:  Curr Genet       Date:  1983-09       Impact factor: 3.886

Review 3.  Leucine biosynthesis in fungi: entering metabolism through the back door.

Authors:  Gunter B Kohlhaw
Journal:  Microbiol Mol Biol Rev       Date:  2003-03       Impact factor: 11.056

4.  Effect of alpha-isopropylmalate on the synthesis of RNA and protein in Neurospora.

Authors:  D Armaleo; M Fischer; S R Gross
Journal:  Mol Gen Genet       Date:  1985

5.  Cloning and expression analysis of beta-isopropylmalate dehydrogenase from potato.

Authors:  S D Jackson; U Sonnewald; L Willmitzer
Journal:  Mol Gen Genet       Date:  1993-01

Review 6.  Chromosomal loci of Neurospora crassa.

Authors:  D D Perkins; A Radford; D Newmeyer; M Björkman
Journal:  Microbiol Rev       Date:  1982-12

7.  Evidence that alpha-isopropylmalate synthase of Saccharomyces cerevisiae is under the "general" control of amino acid biosynthesis.

Authors:  Y P Hsu; G B Kohlhaw; P Niederberger
Journal:  J Bacteriol       Date:  1982-05       Impact factor: 3.490

8.  Specific regulatory interconnection between the leucine and histidine pathways of Neurospora crassa.

Authors:  G L Kidd; S R Gross
Journal:  J Bacteriol       Date:  1984-04       Impact factor: 3.490

9.  Two origins for the gene encoding alpha-isopropylmalate synthase in fungi.

Authors:  Erica M Larson; Alexander Idnurm
Journal:  PLoS One       Date:  2010-07-15       Impact factor: 3.240

10.  Valine inhibition of beta-isopropylmalate dehydrogenase takes part in the regulation of leucine biosynthesis in Candida maltosa.

Authors:  R Bode
Journal:  Antonie Van Leeuwenhoek       Date:  1991-08       Impact factor: 2.271
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