Literature DB >> 14661900

Acute electroretinographic changes during sildenafil (Viagra) treatment for erectile dysfunction.

Corrado Balacco Gabrieli1, Federico Regine, Enzo M Vingolo, Edoardo Rispoli, Aldo Isidori.   

Abstract

The authors describe their findings on 12 subjects who were treated with 50 mg of sildenafil (Viagra) and underwent ERG measurements prior to and 1 hour after ingestion. The Naka-Rushton equation was used to describe the b-wave luminance-response function of the scotopic ERG. Statistically significant differences were noted in the Vmax and K values. Sildenafil ingestion resulted in an increase in Vmax (higher rod response to light stimuli) and a decrease in K (higher sensitivity).

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Year:  2003        PMID: 14661900     DOI: 10.1023/a:1026271404384

Source DB:  PubMed          Journal:  Doc Ophthalmol        ISSN: 0012-4486            Impact factor:   2.379


  4 in total

1.  Sildenafil and erectile dysfunction.

Authors:  A Fabbri; A Aversa; A Isidori
Journal:  J Endocrinol Invest       Date:  1999-06       Impact factor: 4.256

2.  Retinal side-effects of sildenafil.

Authors:  M A Vobig; T Klotz; M Staak; K U Bartz-Schmidt; U Engelmann; P Walter
Journal:  Lancet       Date:  1999-01-30       Impact factor: 79.321

3.  Sildenafil-mediated reduction in retinal function in heterozygous mice lacking the gamma-subunit of phosphodiesterase.

Authors:  D Behn; M J Potter
Journal:  Invest Ophthalmol Vis Sci       Date:  2001-02       Impact factor: 4.799

Review 4.  Sildenafil (Viagra) and ophthalmology.

Authors:  M F Marmor; R Kessler
Journal:  Surv Ophthalmol       Date:  1999 Sep-Oct       Impact factor: 6.048

  4 in total
  6 in total

1.  Dose-dependency and time-course of electrophysiologic short-term effects of VIAGRA: a case study.

Authors:  Herbert Jägle; Christine Jägle; Ludwig Sèrey; Lindsay T Sharpe
Journal:  Doc Ophthalmol       Date:  2005 Mar-May       Impact factor: 2.379

2.  Intensity response function of the photopic negative response (PhNR): effect of age and test-retest reliability.

Authors:  Nabin R Joshi; Emma Ly; Suresh Viswanathan
Journal:  Doc Ophthalmol       Date:  2017-05-15       Impact factor: 2.379

3.  ISCEV extended protocol for the stimulus-response series for the dark-adapted full-field ERG b-wave.

Authors:  Mary A Johnson; Brett G Jeffrey; André M V Messias; Anthony G Robson
Journal:  Doc Ophthalmol       Date:  2019-03-30       Impact factor: 2.379

4.  Ocular toxicity assessment of chronic sildenafil therapy for pulmonary arterial hypertension.

Authors:  Licia Matieli; Adriana Berezovsky; Solange Rios Salomão; Norma Allemann; Elisabeth Nogueira Martins; Flavio E Hirai; Jaquelina Ota-Arakaki; Maira S A Morales; Denise de Freitas
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2016-04-19       Impact factor: 3.117

5.  cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents.

Authors:  Santiago A Plano; Patricia V Agostino; Horacio O de la Iglesia; Diego A Golombek
Journal:  PLoS One       Date:  2012-05-10       Impact factor: 3.240

Review 6.  Pathophysiology of visual disorders induced by phosphodiesterase inhibitors in the treatment of erectile dysfunction.

Authors:  Marilita M Moschos; Eirini Nitoda
Journal:  Drug Des Devel Ther       Date:  2016-10-19       Impact factor: 4.162

  6 in total

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