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Literature DB >> 14657500

Yeast cells provide insight into alpha-synuclein biology and pathobiology.

Tiago Fleming Outeiro¹, Susan Lindquist.

Abstract

Alpha-synuclein is implicated in several neurodegenerative disorders, such as Parkinson's disease and multiple system atrophy, yet its functions remain obscure. When expressed in yeast, alpha-synuclein associated with the plasma membrane in a highly selective manner, before forming cytoplasmic inclusions through a concentration-dependent, nucleated process. Alpha-synuclein inhibited phospholipase D, induced lipid droplet accumulation, and affected vesicle trafficking. This readily manipulable system provides an opportunity to dissect the molecular pathways underlying normal alpha-synuclein biology and the pathogenic consequences of its misfolding.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2003 PMID： 14657500 PMCID： PMC1780172 DOI： 10.1126/science.1090439

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

30 in total

1. Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.

Authors: K A Conway; S J Lee; J C Rochet; T T Ding; R E Williamson; P T Lansbury
Journal: Proc Natl Acad Sci U S A Date: 2000-01-18 Impact factor: 11.205

2. The ubiquitin pathway in Parkinson's disease.

Authors: E Leroy; R Boyer; G Auburger; B Leube; G Ulm; E Mezey; G Harta; M J Brownstein; S Jonnalagada; T Chernova; A Dehejia; C Lavedan; T Gasser; P J Steinbach; K D Wilkinson; M H Polymeropoulos
Journal: Nature Date: 1998-10-01 Impact factor: 49.962

3. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.

Authors: R Krüger; W Kuhn; T Müller; D Woitalla; M Graeber; S Kösel; H Przuntek; J T Epplen; L Schöls; O Riess
Journal: Nat Genet Date: 1998-02 Impact factor: 38.330

4. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.

Authors: T Kitada; S Asakawa; N Hattori; H Matsumine; Y Yamamura; S Minoshima; M Yokochi; Y Mizuno; N Shimizu
Journal: Nature Date: 1998-04-09 Impact factor: 49.962

5. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.

Authors: D D Murphy; S M Rueter; J Q Trojanowski; V M Lee
Journal: J Neurosci Date: 2000-05-01 Impact factor: 6.167

6. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.

Authors: M H Polymeropoulos; C Lavedan; E Leroy; S E Ide; A Dehejia; A Dutra; B Pike; H Root; J Rubenstein; R Boyer; E S Stenroos; S Chandrasekharappa; A Athanassiadou; T Papapetropoulos; W G Johnson; A M Lazzarini; R C Duvoisin; G Di Iorio; L I Golbe; R L Nussbaum
Journal: Science Date: 1997-06-27 Impact factor: 47.728

7. An essential role for a phospholipid transfer protein in yeast Golgi function.

Authors: V A Bankaitis; J R Aitken; A E Cleves; W Dowhan
Journal: Nature Date: 1990-10-11 Impact factor: 49.962

8. SPO14 separation-of-function mutations define unique roles for phospholipase D in secretion and cellular differentiation in Saccharomyces cerevisiae.

Authors: S A Rudge; T R Pettitt; C Zhou; M J Wakelam; J A Engebrecht
Journal: Genetics Date: 2001-08 Impact factor: 4.562

9. Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins.

Authors: J M Jenco; A Rawlingson; B Daniels; A J Morris
Journal: Biochemistry Date: 1998-04-07 Impact factor: 3.162

10. A role for phospholipase D (Pld1p) in growth, secretion, and regulation of membrane lipid synthesis in yeast.

Authors: A Sreenivas; J L Patton-Vogt; V Bruno; P Griac; S A Henry
Journal: J Biol Chem Date: 1998-07-03 Impact factor: 5.157

331 in total

1. Coupling of Human Rhodopsin to a Yeast Signaling Pathway Enables Characterization of Mutations Associated with Retinal Disease.

Authors: Benjamin M Scott; Steven K Chen; Nihar Bhattacharyya; Abdiwahab Y Moalim; Sergey V Plotnikov; Elise Heon; Sergio G Peisajovich; Belinda S W Chang
Journal: Genetics Date: 2018-12-04 Impact factor: 4.562

2. High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment.

Authors: Patrícia Rosa; Sandra Tenreiro; Virginia Chu; Tiago F Outeiro; João Pedro Conde
Journal: Biomicrofluidics Date: 2012-02-09 Impact factor: 2.800

3. Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling.

Authors: Christine C Jao; Ani Der-Sarkissian; Jeannie Chen; Ralf Langen
Journal: Proc Natl Acad Sci U S A Date: 2004-05-20 Impact factor: 11.205

4. Lipid rafts mediate the synaptic localization of alpha-synuclein.

Authors: Doris L Fortin; Matthew D Troyer; Ken Nakamura; Shin-ichiro Kubo; Malcolm D Anthony; Robert H Edwards
Journal: J Neurosci Date: 2004-07-28 Impact factor: 6.167

Review 5. Polyglutamine misfolding in yeast: toxic and protective aggregation.

Authors: Martin L Duennwald
Journal: Prion Date: 2011-10-01 Impact factor: 3.931

6. Triclabendazole protects yeast and mammalian cells from oxidative stress: identification of a potential neuroprotective compound.

Authors: Yong Joo Lee; Elodie Burlet; Shaoxiao Wang; Baoshan Xu; Shile Huang; Floyd J Galiano; Stephan N Witt
Journal: Biochem Biophys Res Commun Date: 2011-09-16 Impact factor: 3.575