Literature DB >> 14648399

Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones.

Hubertus Jarry1, Barbara Spengler, Andrea Porzel, Juergen Schmidt, Wolfgang Wuttke, Volker Christoffel.   

Abstract

Recent cell culture experiments indicated that extracts of Vitex agnus-castus (VAC) may contain yet unidentified phytoestrogens. Estrogenic actions are mediated via estrogen receptors (ER). To investigate whether VAC compounds bind to the currently known isoforms ERalpha or ERss, ligand binding assays (LBA) were performed. Subtype specific ER-LBA revealed a binding of VAC to ERss only. To isolate the ERss-selective compounds, the extract was fractionated by bio-guidance. The flavonoid apigenin was isolated and identified as the most active ERss-selective phytoestrogen in VAC. Other isolated compounds were vitexin and penduletin. These data demonstrate that the phytoestrogens in VAC are ERss-selective.

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Year:  2003        PMID： 14648399     DOI： 10.1055/s-2003-45105

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  13 in total

1.  Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways.

Authors:  Xue Zhang; Chenhui Zhou; Xuan Zha; Zhoumei Xu; Li Li; Yuyu Liu; Liangliang Xu; Liao Cui; Daohua Xu; Baohua Zhu
Journal:  Mol Cell Biochem       Date:  2015-05-21       Impact factor: 3.396

Review 2.  Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings.

Authors:  Susan Arentz; Jason Anthony Abbott; Caroline Anne Smith; Alan Bensoussan
Journal:  BMC Complement Altern Med       Date:  2014-12-18       Impact factor: 3.659

3.  Phytoconstituents from Vitex agnus-castus fruits.

Authors:  Shao-Nong Chen; J Brent Friesen; Donna Webster; Dejan Nikolic; Richard B van Breemen; Z Jim Wang; Harry H S Fong; Norman R Farnsworth; Guido F Pauli
Journal:  Fitoterapia       Date:  2010-12-13       Impact factor: 2.882

Review 4.  Botanicals and Their Bioactive Phytochemicals for Women's Health.

Authors:  Birgit M Dietz; Atieh Hajirahimkhan; Tareisha L Dunlap; Judy L Bolton
Journal:  Pharmacol Rev       Date:  2016-10       Impact factor: 25.468

Review 5.  Botanical modulation of menopausal symptoms: mechanisms of action?

Authors:  Atieh Hajirahimkhan; Birgit M Dietz; Judy L Bolton
Journal:  Planta Med       Date:  2013-02-13       Impact factor: 3.352

6.  A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements.

Authors:  Chelsea N Powers; William N Setzer
Journal:  In Silico Pharmacol       Date:  2015-03-22

Review 7.  Systematic Review of Premenstrual, Postmenstrual and Infertility Disorders of Vitex Agnus Castus.

Authors:  Mahmoud Rafieian-Kopaei; Mino Movahedi
Journal:  Electron Physician       Date:  2017-01-25

8.  Can Vitex Agnus Castus be Used for the Treatment of Mastalgia? What is the Current Evidence?

Authors:  A R Carmichael
Journal:  Evid Based Complement Alternat Med       Date:  2008-09       Impact factor: 2.629

Review 9.  The genus Vitex: A review.

Authors:  Anita Rani; Anupam Sharma
Journal:  Pharmacogn Rev       Date:  2013-07

10.  Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication.

Authors:  Atieh Hajirahimkhan; Obinna Mbachu; Charlotte Simmler; Sarah G Ellis; Huali Dong; Dejan Nikolic; David C Lankin; Richard B van Breemen; Shao-Nong Chen; Guido F Pauli; Birgit M Dietz; Judy L Bolton
Journal:  J Nat Prod       Date:  2018-04-11       Impact factor: 4.050
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