| Literature DB >> 21163339 |
Shao-Nong Chen1, J Brent Friesen, Donna Webster, Dejan Nikolic, Richard B van Breemen, Z Jim Wang, Harry H S Fong, Norman R Farnsworth, Guido F Pauli.
Abstract
A new labdane-diterpene, viteagnusin I (1), together with 23 known phytoconstituents were isolated from the fruits of Vitex agnus-castus L, and their structures characterized by spectroscopic methods (NMR and MS). The known compounds include ten flavonoids, five terpenoids, three neolignans, and four phenolic compounds, as well as one glyceride. Biological evaluation identified apigenin, 3-methylkaempferol, luteolin, and casticin as weak ligands of delta and mu opioid receptors, exhibiting dose-dependent receptor binding.Entities:
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Year: 2010 PMID： 21163339 PMCID： PMC3081944 DOI： 10.1016/j.fitote.2010.12.003
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882