Literature DB >> 14646319

Synthesis and biological evaluation of ebselen and its acyclic derivatives.

Tsu-Chung Chang1, Mei-Lan Huang, Wen-Lin Hsu, Jing-Min Hwang, Ling-Yih Hsu.   

Abstract

Five ebselen and three acyclic ebselen derivatives were synthesized. These compounds were screened for their glutathione peroxidase (GSH Px)-like activity and scavenging activity against 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) and peroxynitrite radical. All tested compounds displayed similar significant GSH Px-like activity, which are slightly higher than that of ebselen. The peroxynitrite scavenging activity showed that the acyclic allylseleno 4c was five times more potent than ebselen.

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Year:  2003        PMID： 14646319     DOI： 10.1248/cpb.51.1413

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  4 in total

1.  Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits.

Authors:  Susan M E Smith; Jaeki Min; Thota Ganesh; Becky Diebold; Tsukasa Kawahara; Yerun Zhu; James McCoy; Aiming Sun; James P Snyder; Haian Fu; Yuhong Du; Iestyn Lewis; J David Lambeth
Journal:  Chem Biol       Date:  2012-06-22

2.  Thermal and Photoinduced Copper-Promoted C-Se Bond Formation: Synthesis of 2-Alkyl-1,2-benzisoselenazol-3(2H)-ones and Evaluation against Mycobacterium tuberculosis.

Authors:  Sandeep Thanna; Christopher M Goins; Susan E Knudson; Richard A Slayden; Donald R Ronning; Steven J Sucheck
Journal:  J Org Chem       Date:  2017-03-20       Impact factor: 4.354

Review 3.  Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory Compounds.

Authors:  Jiajie Zhu; Haiyan Zhang; Qinghong Lin; Jingting Lyu; Lu Lu; Hanxi Chen; Xuning Zhang; Yanjun Zhang; Keda Chen
Journal:  Drug Des Devel Ther       Date:  2022-04-08       Impact factor: 4.319

4.  N-(2-Methyl-phen-yl)-1,2-benzoselen-azol-3(2H)-one.

Authors:  Xu Zhu; Ying Xu; Hongfei Han; Zhiqiang Guo; Xuehong Wei
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-09-12
  4 in total

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