OBJECTIVE: To evaluate gender-related differences in quality of life (QOL) and cognitive function 1 year after coronary artery bypass surgery (CABG) after adjusting for known baseline differences. MATERIALS AND METHODS: Two hundred eighty patients (96 women and 184 men) underwent neurocognitive and QOL evaluation at baseline (preoperatively) and at 1 year after CABG. Multivariable linear regression was used to assess the relationship of gender to follow-up QOL and cognitive function. Measures used to evaluate QOL were IADL, DASI, work activities (SF-36), social activities, social support, general health perception (SF-36), CESD, STAI, and symptom limitations. Cognitive function was measured with a battery of performance-based neuropsychological tests, reduced to a four-cognitive domain scores with factor analysis, and a self-report measure of cognitive difficulties. Covariates in multiple regression models included age, years of education, marital status, Charlson Comorbidity Index, hypertension, diabetes, race, and baseline QOL/cognitive status. RESULTS: Female patients showed significantly worse outcome than male patients at 1 year follow-up in several key areas of QOL. After adjusting for baseline differences, women are at greater risk for increased cognitive difficulties (p= 0.04) and anxiety (p= 0.03), as well as impaired DASI (p= 0.02), IADL (p= 0.03), and work activities (p= 0.02). Cognitive sequelae attributable to bypass surgery were similar between men and women. CONCLUSIONS: Even after adjusting for known risk factors for compromised QOL and cognitive functioning, women do not show the same long-term quality benefits of CABG surgery that men do.
OBJECTIVE: To evaluate gender-related differences in quality of life (QOL) and cognitive function 1 year after coronary artery bypass surgery (CABG) after adjusting for known baseline differences. MATERIALS AND METHODS: Two hundred eighty patients (96 women and 184 men) underwent neurocognitive and QOL evaluation at baseline (preoperatively) and at 1 year after CABG. Multivariable linear regression was used to assess the relationship of gender to follow-up QOL and cognitive function. Measures used to evaluate QOL were IADL, DASI, work activities (SF-36), social activities, social support, general health perception (SF-36), CESD, STAI, and symptom limitations. Cognitive function was measured with a battery of performance-based neuropsychological tests, reduced to a four-cognitive domain scores with factor analysis, and a self-report measure of cognitive difficulties. Covariates in multiple regression models included age, years of education, marital status, Charlson Comorbidity Index, hypertension, diabetes, race, and baseline QOL/cognitive status. RESULTS: Female patients showed significantly worse outcome than male patients at 1 year follow-up in several key areas of QOL. After adjusting for baseline differences, women are at greater risk for increased cognitive difficulties (p= 0.04) and anxiety (p= 0.03), as well as impaired DASI (p= 0.02), IADL (p= 0.03), and work activities (p= 0.02). Cognitive sequelae attributable to bypass surgery were similar between men and women. CONCLUSIONS: Even after adjusting for known risk factors for compromised QOL and cognitive functioning, women do not show the same long-term quality benefits of CABG surgery that men do.
Authors: Ghislaine A P G van Mastrigt; Manuela A Joore; Fred H M Nieman; Johan L Severens; Jos G Maessen Journal: Qual Life Res Date: 2010-03-26 Impact factor: 4.147
Authors: Liza A Prudente; Juanita Reigle; Cheryl Bourguignon; David E Haines; John P DiMarco Journal: J Interv Card Electrophysiol Date: 2006-08-04 Impact factor: 1.900
Authors: Amanda A Fox; Edward R Marcantonio; Charles D Collard; Mathis Thoma; Tjorvi E Perry; Stanton K Shernan; Jochen D Muehlschlegel; Simon C Body Journal: Anesthesiology Date: 2011-04 Impact factor: 7.892
Authors: Bruce L Rollman; Bea Herbeck Belnap; Michelle S LeMenager; Sati Mazumdar; Herbert C Schulberg; Charles F Reynolds Journal: Psychosom Med Date: 2009-02-02 Impact factor: 4.312
Authors: Charles W Hogue; Robert Fucetola; Tamara Hershey; Abullah Nassief; Stanley Birge; Victor G Dávila-Román; Benico Barzilai; Betsy Thomas; Kenneth B Schechtman; Kenneth Freedland Journal: Anesth Analg Date: 2008-07 Impact factor: 5.108
Authors: Bruce L Rollman; Bea Herbeck Belnap; Michelle S LeMenager; Sati Mazumdar; Patricia R Houck; Peter J Counihan; Wishwa N Kapoor; Herbert C Schulberg; Charles F Reynolds Journal: JAMA Date: 2009-11-16 Impact factor: 56.272