OBJECTIVE: Several studies show that the inflammatory component in atherosclerosis may contribute to increased risk for cardiovascular disease (CVD). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-stimulatory cytokine of presumed importance for CVD and the metabolic syndrome. METHODS AND RESULTS: In this case-control study, 1179 surviving myocardial infarction (MI) cases and 1528 healthy controls were genotyped for three IL-6 promoter SNPs, and serum concentrations of IL-6 and C-reactive protein (CRP) were measured. In men, MI risk assessed as odds ratios (OR) was higher with increasing IL-6 levels, with the highest compared to the lowest IL-6 quartiles giving an OR of 2.7 [95% CI 1.7-4.4]. The ORs were independent from the effects of elevated CRP which were associated with modest MI risks (OR = 1.6 [95% CI 1.0-2.5]). Also, synergistic interactions between high IL-6 levels and hypercholesterolaemia further increased MI risk estimates. The -174C allele was associated with lower serum-insulin levels among male controls but did not significantly influence MI risk or IL-6 levels. CONCLUSIONS: Elevated IL-6 levels are important risk markers for MI in men, the risk being further enhanced through synergistic interaction with hypercholesterolaemia. The data provide no clear evidence that polymorphisms in the IL-6 promotor region play a significant role in the pathogenesis of MI, and it remains to be further evaluated whether or not the -174C allele is of relevance for insulin resistance. Copyright 2003 Elsevier Ireland Ltd.
OBJECTIVE: Several studies show that the inflammatory component in atherosclerosis may contribute to increased risk for cardiovascular disease (CVD). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-stimulatory cytokine of presumed importance for CVD and the metabolic syndrome. METHODS AND RESULTS: In this case-control study, 1179 surviving myocardial infarction (MI) cases and 1528 healthy controls were genotyped for three IL-6 promoter SNPs, and serum concentrations of IL-6 and C-reactive protein (CRP) were measured. In men, MI risk assessed as odds ratios (OR) was higher with increasing IL-6 levels, with the highest compared to the lowest IL-6 quartiles giving an OR of 2.7 [95% CI 1.7-4.4]. The ORs were independent from the effects of elevated CRP which were associated with modest MI risks (OR = 1.6 [95% CI 1.0-2.5]). Also, synergistic interactions between high IL-6 levels and hypercholesterolaemia further increased MI risk estimates. The -174C allele was associated with lower serum-insulin levels among male controls but did not significantly influence MI risk or IL-6 levels. CONCLUSIONS: Elevated IL-6 levels are important risk markers for MI in men, the risk being further enhanced through synergistic interaction with hypercholesterolaemia. The data provide no clear evidence that polymorphisms in the IL-6 promotor region play a significant role in the pathogenesis of MI, and it remains to be further evaluated whether or not the -174C allele is of relevance for insulin resistance. Copyright 2003 Elsevier Ireland Ltd.
Authors: Hagit Katzov; Anna M Bennet; Kina Höglund; Björn Wiman; Dieter Lütjohann; Anthony J Brookes; Niels Andreasen; Kaj Blennow; Ulf De Faire; Jonathan A Prince Journal: J Hum Genet Date: 2005-12-22 Impact factor: 3.172
Authors: Yueh-Hsiu Mathilda Chiu; Eric Garshick; Jaime E Hart; Donna Spiegelman; Douglas W Dockery; Thomas J Smith; Francine Laden Journal: Environ Res Date: 2016-04-19 Impact factor: 6.498
Authors: Cornelia Huth; Thomas Illig; Christian Herder; Christian Gieger; Harald Grallert; Caren Vollmert; Wolfgang Rathmann; Yasmin H Hamid; Oluf Pedersen; Torben Hansen; Barbara Thorand; Christa Meisinger; Angela Doring; Norman Klopp; Henning Gohlke; Wolfgang Lieb; Christian Hengstenberg; Valeriya Lyssenko; Leif Groop; Helen Ireland; Jeffrey W Stephens; Ingrid Wernstedt Asterholm; John-Olov Jansson; Heiner Boeing; Matthias Mohlig; Heather M Stringham; Michael Boehnke; Jaakko Tuomilehto; Jose-Manuel Fernandez-Real; Abel Lopez-Bermejo; Luis Gallart; Joan Vendrell; Steve E Humphries; Florian Kronenberg; H-Erich Wichmann; Iris M Heid Journal: Ann Med Date: 2009 Impact factor: 4.709