Jaime E Hart1, Tianying Wu, Francine Laden, Eric Garshick. 1. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. jaime.hart@channing.harvard.edu
Abstract
BACKGROUND: Evidence suggests that fine particulate air pollution results in oxidative induced tissue damage. METHODS: A global fluorescent oxidation products (FLOx) assay (fluorescent intensity (FI) units per milliliter of plasma) was measured in blood samples collected from 236 nonsmoking, Caucasian, male trucking industry workers either prior to, during, or after their work shifts. Occupational exposures to particulate matter (PM)(2.5) were based on job-specific area-level sampling. Generalized linear models were used to determine associations between FLOx levels and PM(2.5) , adjusted for age, time since last meal, alcohol consumption, aspirin, and cholesterol medications. RESULTS: The mean (standard deviation) level of FLOx was 265.9 FI/ml (96.0). Levels of FLOx were higher among older individuals and lower among those who had consumed alcohol in the past 24 hr. However, no associations were observed between FLOx and PM(2.5) . CONCLUSIONS: Our results indicate no association between occupational PM(2.5) exposure and this marker of global oxidative stress.
BACKGROUND: Evidence suggests that fine particulate air pollution results in oxidative induced tissue damage. METHODS: A global fluorescent oxidation products (FLOx) assay (fluorescent intensity (FI) units per milliliter of plasma) was measured in blood samples collected from 236 nonsmoking, Caucasian, male trucking industry workers either prior to, during, or after their work shifts. Occupational exposures to particulate matter (PM)(2.5) were based on job-specific area-level sampling. Generalized linear models were used to determine associations between FLOx levels and PM(2.5) , adjusted for age, time since last meal, alcohol consumption, aspirin, and cholesterol medications. RESULTS: The mean (standard deviation) level of FLOx was 265.9 FI/ml (96.0). Levels of FLOx were higher among older individuals and lower among those who had consumed alcohol in the past 24 hr. However, no associations were observed between FLOx and PM(2.5) . CONCLUSIONS: Our results indicate no association between occupational PM(2.5) exposure and this marker of global oxidative stress.
Authors: Marko Tainio; Jouni T Tuomisto; Otto Hänninen; Päivi Aarnio; Kimmo J Koistinen; Matti J Jantunen; Juha Pekkanen Journal: Risk Anal Date: 2005-02 Impact factor: 4.000
Authors: A Peters; E Liu; R L Verrier; J Schwartz; D R Gold; M Mittleman; J Baliff; J A Oh; G Allen; K Monahan; D W Dockery Journal: Epidemiology Date: 2000-01 Impact factor: 4.822
Authors: C Arden Pope; Richard T Burnett; George D Thurston; Michael J Thun; Eugenia E Calle; Daniel Krewski; John J Godleski Journal: Circulation Date: 2003-12-15 Impact factor: 29.690
Authors: Matteo Cesari; Brenda W J H Penninx; Anne B Newman; Stephen B Kritchevsky; Barbara J Nicklas; Kim Sutton-Tyrrell; Russell P Tracy; Susan M Rubin; Tamara B Harris; Marco Pahor Journal: Am J Cardiol Date: 2003-09-01 Impact factor: 2.778