| Literature DB >> 14643344 |
Won-Jea Cho1, Sun Young Min, Thanh Nguyen Le, Tae Sung Kim.
Abstract
To investigate the structure-activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I-DNA complex was also performed.Entities:
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Year: 2003 PMID： 14643344 DOI： 10.1016/j.bmcl.2003.09.001
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823