| Literature DB >> 14643341 |
Susanna Bosi1, Tatiana Da Ros, Giampiero Spalluto, Jan Balzarini, Maurizio Prato.
Abstract
A new series of bis-functionalized fullerene C(60) derivatives bearing two or more solubilizing chains have been evaluated for their activity against HIV-1 and HIV-2 strains. Some of the compounds show activity against HIV-1 type in the low micromolar range. The effect of the positions of the addends on the C(60) nucleus has been investigated, indicating that only trans-2 isomers possess promising activity. The presence of a quaternary pyrrolidinium nitrogen is essential to increase solubility.Entities:
Mesh：
Substances：
Year: 2003 PMID： 14643341 DOI： 10.1016/j.bmcl.2003.09.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823