| Literature DB >> 14642594 |
Ayumu Kurimoto1, Tetsuhiro Ogino, Shinji Ichii, Yoshiaki Isobe, Masanori Tobe, Haruhisa Ogita, Haruo Takaku, Hironao Sajiki, Kosaku Hirota, Hajime Kawakami.
Abstract
Recently, we have reported the 8-hydroxyadenine derivatives (2-4) as a novel class of interferon (IFN) inducing agents. In the present study, a series of 8-hydroxyadenines, which possess various amino moieties at the adenine C(2)-position, were synthesized and evaluated for their ability to induce endogenous IFN in comparison to the known active agent, Imiquimod. Among the compounds prepared, compound 9o possessing a 2-methoxyethylamino group at C(2)-position of adenine was found to exhibit potent IFN inducing activity in vivo. Compound 9o induced IFN from the dosage of 0.1 mg/kg, which was 30-fold potent than that of Imiquimod, and showed a good oral bioavailability (F=81%).Entities:
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Year: 2003 PMID： 14642594 DOI： 10.1016/j.bmc.2003.09.032
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641