John G R Jefferys1. 1. Division of Neuroscience (Neurophysiology), School of Medicine, University of Birmingham, Birmingham, England, UK. j.g.r.jefferys@bham.ac.uk
Abstract
PURPOSE: To review the value of experimental models of epilepsy to help us understand the underlying basic neuronal mechanisms. METHODS: The methods addressed here include a variety of acute and chronic experimental epilepsies and their investigation in vitro, in vivo, and in computer simulations. RESULTS: Epileptic discharges are emergent properties of neuronal networks, depending crucially on intrinsic neuronal properties, and on the structural and functional organisation of the synaptic networks that interconnect them. Fast oscillations are another emergent property of these networks; while they are involved in normal function, they can play a crucial role in the initiation of at least some kinds of focal seizure. DISCUSSION: Brief "interictal" epileptic events are now relatively well understood. Rather less so are the mechanisms of chronic epileptic foci, and particularly of the prolonged hypersynchronous hyperexcitability characteristic of focal seizures, but here too progress is being made, offering the prospect of better targeted treatments.
PURPOSE: To review the value of experimental models of epilepsy to help us understand the underlying basic neuronal mechanisms. METHODS: The methods addressed here include a variety of acute and chronic experimental epilepsies and their investigation in vitro, in vivo, and in computer simulations. RESULTS:Epileptic discharges are emergent properties of neuronal networks, depending crucially on intrinsic neuronal properties, and on the structural and functional organisation of the synaptic networks that interconnect them. Fast oscillations are another emergent property of these networks; while they are involved in normal function, they can play a crucial role in the initiation of at least some kinds of focal seizure. DISCUSSION: Brief "interictal" epileptic events are now relatively well understood. Rather less so are the mechanisms of chronic epileptic foci, and particularly of the prolonged hypersynchronous hyperexcitability characteristic of focal seizures, but here too progress is being made, offering the prospect of better targeted treatments.
Authors: Rodrigo Bainy Leal; Mark William Lopes; Douglas Affonso Formolo; Cristiane Ribeiro de Carvalho; Alexandre Ademar Hoeller; Alexandra Latini; Daniel Santos Sousa; Peter Wolf; Rui Daniel Prediger; Zuner Assis Bortolotto; Marcelo Neves Linhares; Kátia Lin; Roger Walz Journal: Mol Psychiatry Date: 2018-06-07 Impact factor: 15.992
Authors: Wilson Truccolo; Jacob A Donoghue; Leigh R Hochberg; Emad N Eskandar; Joseph R Madsen; William S Anderson; Emery N Brown; Eric Halgren; Sydney S Cash Journal: Nat Neurosci Date: 2011-03-27 Impact factor: 24.884