Literature DB >> 14638516

Efficacy of sulforaphane in eradicating Helicobacter pylori in human gastric xenografts implanted in nude mice.

Xavier Haristoy1, Karine Angioi-Duprez, Adrien Duprez, Alain Lozniewski.   

Abstract

Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts, has shown in vitro activity against Helicobacter pylori. We evaluated the effect of sulforaphane in vivo against this bacterium by using human gastric xenografts in nude mice. H. pylori was completely eradicated in 8 of the 11 sulforaphane-treated grafts. This result suggests that sulforaphane might be beneficial in the treatment of H. pylori-infected individuals.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14638516      PMCID： PMC296232          DOI： 10.1128/AAC.47.12.3982-3984.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  34 in total

Review 1.  The gastrointestinal tract: a major site of antioxidant action?

Authors:  B Halliwell; K Zhao; M Whiteman
Journal:  Free Radic Res       Date:  2000-12

2.  Resveratrol inhibits the growth of Helicobacter pylori in vitro.

Authors:  G B Mahady; S L Pendland
Journal:  Am J Gastroenterol       Date:  2000-07       Impact factor: 10.864

3.  Allixin, a phytoalexin from garlic, inhibits the growth of Helicobacter pylori in vitro.

Authors:  G B Mahady; H Matsuura; S L Pendland
Journal:  Am J Gastroenterol       Date:  2001-12       Impact factor: 10.864

4.  Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.

Authors:  T A Shapiro; J W Fahey; K L Wade; K K Stephenson; P Talalay
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2001-05       Impact factor: 4.254

5.  A pilot study to determine the effectiveness of garlic oil capsules in the treatment of dyspeptic patients with Helicobacter pylori.

Authors:  C A McNulty; M P Wilson; W Havinga; B Johnston; E A O'Gara; D J Maslin
Journal:  Helicobacter       Date:  2001-09       Impact factor: 5.753

6.  Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.

Authors:  Jed W Fahey; Xavier Haristoy; Patrick M Dolan; Thomas W Kensler; Isabelle Scholtus; Katherine K Stephenson; Paul Talalay; Alain Lozniewski
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

Review 7.  The chemical diversity and distribution of glucosinolates and isothiocyanates among plants.

Authors:  J W Fahey; A T Zalcmann; P Talalay
Journal:  Phytochemistry       Date:  2001-01       Impact factor: 4.072

8.  Helicobacter pylori entry into human gastric epithelial cells: A potential determinant of virulence, persistence, and treatment failures.

Authors:  B Björkholm; V Zhukhovitsky; C Löfman; K Hultén; H Enroth; M Block; R Rigo; P Falk; L Engstrand
Journal:  Helicobacter       Date:  2000-09       Impact factor: 5.753

9.  Antibacterial action of tryptanthrin and kaempferol, isolated from the indigo plant (Polygonum tinctorium Lour.), against Helicobacter pylori-infected Mongolian gerbils.

Authors:  M Kataoka; K Hirata; T Kunikata; S Ushio; K Iwaki; K Ohashi; M Ikeda; M Kurimoto
Journal:  J Gastroenterol       Date:  2001-01       Impact factor: 7.527

10.  In vitro anti-Helicobacter pylori activity of panaxytriol isolated from ginseng.

Authors:  E A Bae; M J Han; N I Baek; D H Kim
Journal:  Arch Pharm Res       Date:  2001-08       Impact factor: 4.946
View more
  20 in total

Review 1.  Functional foods and their role in cancer prevention and health promotion: a comprehensive review.

Authors:  Mohammad Aghajanpour; Mohamad Reza Nazer; Zia Obeidavi; Mohsen Akbari; Parya Ezati; Nasroallah Moradi Kor
Journal:  Am J Cancer Res       Date:  2017-04-01       Impact factor: 6.166

2.  Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention.

Authors:  Omkara L Veeranki; Arup Bhattacharya; James R Marshall; Yuesheng Zhang
Journal:  Br J Nutr       Date:  2012-04-02       Impact factor: 3.718

Review 3.  Dietary amelioration of Helicobacter infection.

Authors:  Jed W Fahey; Katherine K Stephenson; Alison J Wallace
Journal:  Nutr Res       Date:  2015-03-06       Impact factor: 3.315

Review 4.  Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.

Authors:  Jane V Higdon; Barbara Delage; David E Williams; Roderick H Dashwood
Journal:  Pharmacol Res       Date:  2007-01-25       Impact factor: 7.658

Review 5.  Exploring alternative treatments for Helicobacter pylori infection.

Authors:  Guadalupe Ayala; Wendy Itzel Escobedo-Hinojosa; Carlos Felipe de la Cruz-Herrera; Irma Romero
Journal:  World J Gastroenterol       Date:  2014-02-14       Impact factor: 5.742

6.  Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, China.

Authors:  Kristin A Moy; Jian-Min Yuan; Fung-Lung Chung; Xue-Li Wang; David Van Den Berg; Renwei Wang; Yu-Tang Gao; Mimi C Yu
Journal:  Int J Cancer       Date:  2009-12-01       Impact factor: 7.396

7.  Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway.

Authors:  Shih-Hui Li; Junsheng Fu; Dara Nall Watkins; Rakesh K Srivastava; Sharmila Shankar
Journal:  Mol Cell Biochem       Date:  2012-11-06       Impact factor: 3.396

Review 8.  The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease.

Authors:  Marcus J Calkins; Delinda A Johnson; Jessica A Townsend; Marcelo R Vargas; James A Dowell; Tracy P Williamson; Andrew D Kraft; Jong-Min Lee; Jiang Li; Jeffrey A Johnson
Journal:  Antioxid Redox Signal       Date:  2009-03       Impact factor: 8.401

Review 9.  Chemoprotection by sulforaphane: keep one eye beyond Keap1.

Authors:  Melinda C Myzak; Roderick H Dashwood
Journal:  Cancer Lett       Date:  2006-02-28       Impact factor: 8.679

10.  Sulforaphane promotes chlamydial infection by suppressing mitochondrial protein oxidation and activation of complement C3.

Authors:  Daniel Saez; Rosine Dushime; Hanzhi Wu; Lourdes B Ramos Cordova; Kirtikar Shukla; Heather Brown-Harding; Cristina M Furdui; Allen W Tsang
Journal:  Protein Sci       Date:  2019-01       Impact factor: 6.725
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.