| Literature DB >> 14633668 |
Olli H J Gröhn1, Piia K Valonen, Kimmo K Lehtimäki, Tuula H Väisänen, Mikko I Kettunen, Seppo Ylä-Herttuala, Risto A Kauppinen, Michael Garwood.
Abstract
Magnetic resonance imaging relaxation times, T(1rho) and Carr-Purcell T(2) (CP-T(2)), were measured in a glioma herpes simplex virus-thymidine kinase gene therapy model. In treated tumors with >50% cell death by histology, T(1rho) and CP-T(2) measured with short spacing (tau(CP)) between centers of adiabatic refocusing pulses showed similar enhanced sensitivity to cytotoxic cell damage over CP-T(2) measured with long tau(CP) (long-tau(CP) T(2): 54.3 +/- 0.7 and 55.4 +/- 1.2 ms, P = 0.30; short-tau(CP) T(2): 61.3 +/- 1.0 and 64.2 +/- 1.1 ms, P < 0.05 before and day 2 of treatment, respectively). Without treatment, long-tau(CP) T(2) provided the most pronounced contrast between tumor and normal cerebral tissue. These data demonstrate that endogenous T(2) contrast can be modulated and extended in a manner likely to be clinically important.Entities:
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Year: 2003 PMID： 14633668
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701