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Literature DB >> 146324

Urinary bladder neoplasms in Syrian hamsters after administration of N-nitroso-N-methyl-N-dodecylamine.

Abstract

The biological effect of N-nitroso-N-methyl-N-dodecylamine (NMDA) was examined in Syrian hamsters as part of a comparative study. Data obtained show that after intragastric administration of NMDA, the urinary bladder was the main target organ for the carcinogenic effect. Transitional cell neoplasms developed and a positive dose response relationship was observed. Lung tumors occurred only in female hamsters, whereas males more frequently showed neoplasms of the nasal cavity and digestive tract.

Entities: Chemical Disease Species

Mesh：

Substances：
Amines

Year: 1977 PMID： 146324 DOI： 10.1007/bf00284296

Source DB: PubMed Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol ISSN： 0084-5353

11 in total

1. [Liver and bladder carcinomas in the guinea pig following di-n-butylnitrosamine administration].

Authors: S Ivankovic; J Bücheler
Journal: Z Krebsforsch Date: 1968

2. [Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].

Authors: H Druckrey; R Preussmann; S Ivankovic; D Schmähl
Journal: Z Krebsforsch Date: 1967

3. Carcinogenic effect of dibutylnitrosamine in European hamsters (Cricetus cricetus).

Authors: J Althoff; U Mohr; N Page; G Reznik
Journal: J Natl Cancer Inst Date: 1974-09 Impact factor: 13.506

4. Nitrosation of tertiary amines and some biologic implications.

Authors: W Lijinsky; L Keefer; E Conrad; R Van de Bogart
Journal: J Natl Cancer Inst Date: 1972-11 Impact factor: 13.506

5. The carcinogenic activity of dibutylnitrosamine in IF x C57 mice.

Authors: M Wood; A Flaks; D B Clayson
Journal: Eur J Cancer Date: 1970-10 Impact factor: 9.162

6. Dibutylnitrosamine carcinogenesis in Syrian Golden and Chinese hamsters.

Authors: J Althoff; F W Krüger; U Mohr; D Schmahl
Journal: Proc Soc Exp Biol Med Date: 1971-01

7. Carcinogenicity of 4-hydroxybutyl-butylnitrosamine in Syrian hamsters.

Authors: J Althoff; F W Krüger
Journal: Cancer Lett Date: 1975-09 Impact factor: 8.679

8. Induction of urinary bladder tumors in rats by administration nitrosomethyldodecylamine.

Authors: W Lijinsky; H W Taylor
Journal: Cancer Res Date: 1975-04 Impact factor: 12.701

9. Induction of urinary bladder tumors in ACI-N rats by butyl(3-carboxypropyl)nitrosoamine, a major urinary metabolite of butyl-(4-hydroxybutyl)nitrosoamine.

Authors: Y Hashimoto; E Suzuki; M Okada
Journal: Gan Date: 1972-10

Urinary bladder neoplasms in Syrian hamsters after administration of N-nitroso-N-methyl-N-dodecylamine.

1. [Liver and bladder carcinomas in the guinea pig following di-n-butylnitrosamine administration].

2. [Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].

3. Carcinogenic effect of dibutylnitrosamine in European hamsters (Cricetus cricetus).

4. Nitrosation of tertiary amines and some biologic implications.

5. The carcinogenic activity of dibutylnitrosamine in IF x C57 mice.

6. Dibutylnitrosamine carcinogenesis in Syrian Golden and Chinese hamsters.

7. Carcinogenicity of 4-hydroxybutyl-butylnitrosamine in Syrian hamsters.

8. Induction of urinary bladder tumors in rats by administration nitrosomethyldodecylamine.

9. Induction of urinary bladder tumors in ACI-N rats by butyl(3-carboxypropyl)nitrosoamine, a major urinary metabolite of butyl-(4-hydroxybutyl)nitrosoamine.

10. Induction of bladder tumours in mice with dibutylnitrosamine.

Review 1. Structure-activity relations in carcinogenesis by N-nitroso compounds.

2. Histopathology of N-methyl-N-nitrosourea-induced mesenchymal tumours of the rat urinary bladder.

3. Ultrastructure of tumors induced in the rat urinary bladder by nitrosomethyldodecylamine.

4. The induction of bladder tumors in F344 rats by intravesicular administration of some nitrosamines.