AIM: To make a prospective assessment of close family members of patients with coeliac disease (CD) by testing their endomysium (EMA) and antigliadin antibodies once a year over a period of 12 y and to investigate whether and when they would develop a positive serology for CD while on a gluten-containing diet. METHODS: Since first-degree relatives of CD patients have a high prevalence of CD, we screened 92 children and adolescents, all first-degree relatives of coeliac patients, for EMA and total IgA antibodies, once a year. RESULTS: Among 11 relatives, at the time of the first screening, 6 already had a positive serology and histology for CD, while 5 became positive only after a period of 2 to 5 y of negative testing. The jejunal mucosa biopsy of these five relatives with retarded positive serology for CD showed a flat mucosa in four of them and a partial villous atrophy in one. They were all HLA DQ2 positive and clinically silent for CD. CONCLUSION: CD can manifest itself after years of negative serological testing.
AIM: To make a prospective assessment of close family members of patients with coeliac disease (CD) by testing their endomysium (EMA) and antigliadin antibodies once a year over a period of 12 y and to investigate whether and when they would develop a positive serology for CD while on a gluten-containing diet. METHODS: Since first-degree relatives of CDpatients have a high prevalence of CD, we screened 92 children and adolescents, all first-degree relatives of coeliac patients, for EMA and total IgA antibodies, once a year. RESULTS: Among 11 relatives, at the time of the first screening, 6 already had a positive serology and histology for CD, while 5 became positive only after a period of 2 to 5 y of negative testing. The jejunal mucosa biopsy of these five relatives with retarded positive serology for CD showed a flat mucosa in four of them and a partial villous atrophy in one. They were all HLA DQ2 positive and clinically silent for CD. CONCLUSION:CD can manifest itself after years of negative serological testing.
Authors: Margaretha M S Wessels; Nicky de Rooij; Lian Roovers; Jan Verhage; Willemien de Vries; M Luisa Mearin Journal: Eur J Pediatr Date: 2018-07-04 Impact factor: 3.183
Authors: Joseph A Murray; S Breanndan Moore; Carol T Van Dyke; Brian D Lahr; Ross A Dierkhising; Alan R Zinsmeister; L Joseph Melton; Cynthia M Kroning; Mounif El-Yousseff; Albert J Czaja Journal: Clin Gastroenterol Hepatol Date: 2007-10-24 Impact factor: 11.382
Authors: Rosa H Uenishi; Lenora Gandolfi; Lucas M Almeida; Patrícia M Fritsch; Fernanda C Almeida; Yanna K M Nóbrega; Riccardo Pratesi Journal: BMC Gastroenterol Date: 2014-02-20 Impact factor: 3.067