Prashant Singh1, Shubhangi Arora2, Suman Lal3, Tor A Strand4, Govind K Makharia5. 1. Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. 2. Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. 3. Max Healthcare, Gurgaon, India. 4. Medical Services Division, Innlandet Hospital Trust, Lillehammer, Norway. 5. Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.
Abstract
OBJECTIVES: First-degree relatives (FDRs) of patients with celiac disease (CD) are at high risk for CD and prevalence among them varies from 1.6 to 38%. The risk of having CD among FDRs if the FDR is sister, brother, mother, father, son, or daughter of index patient with CD is not known. We conducted a meta-analysis and calculated pooled prevalence of CD among FDRs, second-degree relatives (SDRs), and specific relations with index patient. METHODS: On search of literature, 2,259 articles appeared of which 54 articles were included in this meta-analysis. Diagnosis of CD was based on standard criteria. RESULTS: Pooled prevalence of CD was 7.5% (95% confidence interval (CI) 6.3%, 8.8%) in 10,252 FDRs and 2.3% (95% CI 1.3%, 3.8%) in 642 SDRs. Pooled prevalence of CD was highest in siblings (8.9%), followed by offsprings (7.9%) and parents (3.0%). Female FDRs had higher prevalence than male FDRs (8.4% vs. 5.2%, P=0.047). While sisters and daughters of index patient had the highest risk of having CD (1 in 7 and 1 in 8, respectively), the risk was 1 in 13 in sons, 1 in 16 in brothers, 1 in 32 in mothers, and 1 in 33 in fathers. There were also differences in the pooled prevalence of CD in FDRs according to their geographic location. CONCLUSIONS: Pooled prevalence of CD among FDRs is 7.5% and varies considerably with their relationship with the index patient. The risk of CD in FDRs also varies according to gender and geographical location.
OBJECTIVES: First-degree relatives (FDRs) of patients with celiac disease (CD) are at high risk for CD and prevalence among them varies from 1.6 to 38%. The risk of having CD among FDRs if the FDR is sister, brother, mother, father, son, or daughter of index patient with CD is not known. We conducted a meta-analysis and calculated pooled prevalence of CD among FDRs, second-degree relatives (SDRs), and specific relations with index patient. METHODS: On search of literature, 2,259 articles appeared of which 54 articles were included in this meta-analysis. Diagnosis of CD was based on standard criteria. RESULTS: Pooled prevalence of CD was 7.5% (95% confidence interval (CI) 6.3%, 8.8%) in 10,252 FDRs and 2.3% (95% CI 1.3%, 3.8%) in 642 SDRs. Pooled prevalence of CD was highest in siblings (8.9%), followed by offsprings (7.9%) and parents (3.0%). Female FDRs had higher prevalence than male FDRs (8.4% vs. 5.2%, P=0.047). While sisters and daughters of index patient had the highest risk of having CD (1 in 7 and 1 in 8, respectively), the risk was 1 in 13 in sons, 1 in 16 in brothers, 1 in 32 in mothers, and 1 in 33 in fathers. There were also differences in the pooled prevalence of CD in FDRs according to their geographic location. CONCLUSIONS: Pooled prevalence of CD among FDRs is 7.5% and varies considerably with their relationship with the index patient. The risk of CD in FDRs also varies according to gender and geographical location.
Authors: Margarida M Castro-Antunes; Roberta Magalhães; Josemar M M Nobre; Bruna P Duarte; Bruna P Silva; Giselia A P Silva Journal: J Pediatr (Rio J) Date: 2010 Jul-Aug Impact factor: 2.197
Authors: Dorottya Kocsis; Pál Miheller; Katalin Lőrinczy; László Herszényi; Zsolt Tulassay; Károly Rácz; Márk Juhász Journal: Eur J Intern Med Date: 2013-03-24 Impact factor: 4.487
Authors: Shirley Ramos da Rosa Utiyama; Flávia Raphaela Nass; Lorete Maria da Silva Kotze; Renato Mitsunori Nisihara; Altair Rogério Ambrosio; Iara Taborda de Messias-Reason Journal: Arq Gastroenterol Date: 2007 Apr-Jun
Authors: Margaretha M S Wessels; Nicky de Rooij; Lian Roovers; Jan Verhage; Willemien de Vries; M Luisa Mearin Journal: Eur J Pediatr Date: 2018-07-04 Impact factor: 3.183