| Literature DB >> 14630796 |
Hidenori Hase1, Yumiko Kanno, Masaru Kojima, Kaoru Hasegawa, Daisuke Sakurai, Hidefumi Kojima, Naoyuki Tsuchiya, Katsushi Tokunaga, Nobuhide Masawa, Miyuki Azuma, Ko Okumura, Tetsuji Kobata.
Abstract
The tumor necrosis factor (TNF)-like ligand BAFF/BLyS (B-cell activating factor of the TNF family/B-lymphocyte stimulator) is a potent B-cell survival factor, yet its functional relationship with other B-cell surface molecules such as CD19 and CD40 is poorly understood. We found that follicular dendritic cells (FDCs) in human lymph nodes expressed BAFF abundantly. BAFF up-regulated a B cell-specific transcription factor Pax5/BSAP (Pax5/B cell-specific activator protein) activity and its target CD19, a major component of the B-cell coreceptor complex, and synergistically enhanced CD19 phosphorylation by B-cell antigen receptor (BCR). BAFF further enhanced B-cell proliferation, immunoglobulin G (IgG) production, and reactivity to CD154 by BCR/CD19 coligation and interleukin-15 (IL-15). Our results suggest that BAFF may play an important role in FDC-B-cell interactions through the B-cell coreceptor complex and a possibly sequential link between the T cell-independent and -dependent B-cell responses in the germinal centers.Entities:
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Year: 2003 PMID： 14630796 DOI： 10.1182/blood-2003-08-2694
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113