| Literature DB >> 25902483 |
Varsha Kumar1, Dragos C Dasoveanu1, Susan Chyou1, Te-Chen Tzeng1, Cristina Rozo1, Yong Liang2, William Stohl3, Yang-Xin Fu2, Nancy H Ruddle4, Theresa T Lu5.
Abstract
Within secondary lymphoid tissues, stromal reticular cells support lymphocyte function, and targeting reticular cells is a potential strategy for controlling pathogenic lymphocytes in disease. However, the mechanisms that regulate reticular cell function are not well understood. Here we found that during an immune response in lymph nodes, dendritic cells (DCs) maintain reticular cell survival in multiple compartments. DC-derived lymphotoxin beta receptor (LTβR) ligands were critical mediators, and LTβR signaling on reticular cells mediated cell survival by modulating podoplanin (PDPN). PDPN modulated integrin-mediated cell adhesion, which maintained cell survival. This DC-stromal axis maintained lymphocyte survival and the ongoing immune response. Our findings provide insight into the functions of DCs, LTβR, and PDPN and delineate a DC-stromal axis that can potentially be targeted in autoimmune or lymphoproliferative diseases.Entities:
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Year: 2015 PMID： 25902483 PMCID： PMC4591553 DOI： 10.1016/j.immuni.2015.03.015
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745