| Literature DB >> 14623019 |
David A Campbell1, Sean Thomas, Nancy R Sturm.
Abstract
Transcription in the kinetoplastid protozoa shows substantial variation from the paradigms of eukaryotic gene expression, including polycistronic transcription, a paucity of RNA polymerase (RNAP) II promoters, no qualitative regulated transcription initiation for most protein-coding genes, transcription of some protein-coding genes by RNAP I, an exclusive subnuclear location for VSG transcription, the dependence of small nuclear RNA gene transcription on an upstream tRNA gene, and the synthesis of mitochondrial tRNAs in the nucleus. Here, we present a broad overview of what is known about transcription in the kinetoplastids and what has yet to be determined.Mesh：
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Year: 2003 PMID： 14623019 DOI： 10.1016/j.micinf.2003.09.005
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700