| Literature DB >> 14623003 |
Upinder Singh1, B Raju, Stuart Lam, Joseph Zhou, Robert C Gadwood, Charles W Ford, Gary E Zurenko, Ronda D Schaadt, Sara E Morin, Wade J Adams, Janice M Friis, Maria Courtney, Joe Palandra, Corinne J Hackbarth, Sara Lopez, Charlotte Wu, Kathleen H Mortell, Joaquim Trias, Zhengyu Yuan, Dinesh V Patel, Mikhail F Gordeev.
Abstract
Combinatorial libraries of N-acylated 5-(S)-aminomethyloxazolidinone derivatives of S-oxide and S,S-dioxide tetrahydro-4(2H)-thiopyranyl and thiomorpholine phenyloxazolidinone series have been synthesized on a solid phase and evaluated for antimicrobial activity. Several novel potent leads have been identified, including orally active oxazolidinones with enhanced activity against respiratory tract infection pathogens Haemophilus influenzae and Moraxella catarrhalis.Entities:
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Year: 2003 PMID： 14623003 DOI： 10.1016/j.bmcl.2003.07.022
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823