Literature DB >> 14617668

FolM, a new chromosomally encoded dihydrofolate reductase in Escherichia coli.

Moshe Giladi1, Neta Altman-Price, Itay Levin, Liat Levy, Moshe Mevarech.   

Abstract

Escherichia coli (thyA DeltafolA) mutants are viable and can grow in minimal medium when supplemented with thymidine alone. Here we present evidence from in vivo and in vitro studies that the ydgB gene determines an alternative dihydrofolate reductase that is related to the trypanosomatid pteridine reductases. We propose to rename this gene folM.

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Year:  2003        PMID： 14617668      PMCID： PMC262705          DOI： 10.1128/JB.185.23.7015-7018.2003

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  12 in total

1.  Genetic evidence for a novel thymidylate synthase in the halophilic archaeon Halobacterium salinarum and in Campylobacter jejuni.

Authors:  Moshe Giladi; Gili Bitan-Banin; Moshe Mevarech; Ron Ortenberg
Journal:  FEMS Microbiol Lett       Date:  2002-10-29       Impact factor: 2.742

2.  One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.

Authors:  K A Datsenko; B L Wanner
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

3.  The presence and distribution of reduced folates in Escherichia coli dihydrofolate reductase mutants.

Authors:  S F Hamm-Alvarez; A Sancar; K V Rajagopalan
Journal:  J Biol Chem       Date:  1990-06-15       Impact factor: 5.157

4.  Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1.

Authors:  J Wang; E Leblanc; C F Chang; B Papadopoulou; T Bray; J M Whiteley; S X Lin; M Ouellette
Journal:  Arch Biochem Biophys       Date:  1997-06-15       Impact factor: 4.013

5.  Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites.

Authors:  D G Gourley; A W Schüttelkopf; G A Leonard; J Luba; L W Hardy; S M Beverley; W N Hunter
Journal:  Nat Struct Biol       Date:  2001-06

6.  The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major.

Authors:  B Nare; L W Hardy; S M Beverley
Journal:  J Biol Chem       Date:  1997-05-23       Impact factor: 5.157

7.  Isogenic P-fimbrial deletion mutants of pyelonephritogenic Escherichia coli: the role of alpha Gal(1-4) beta Gal binding in virulence of a wild-type strain.

Authors:  H L Mobley; K G Jarvis; J P Elwood; D I Whittle; C V Lockatell; R G Russell; D E Johnson; M S Donnenberg; J W Warren
Journal:  Mol Microbiol       Date:  1993-10       Impact factor: 3.501

8.  PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.

Authors:  A R Bello; B Nare; D Freedman; L Hardy; S M Beverley
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-22       Impact factor: 11.205

9.  Construction of a dihydrofolate reductase-deficient mutant of Escherichia coli by gene replacement.

Authors:  E E Howell; P G Foster; L M Foster
Journal:  J Bacteriol       Date:  1988-07       Impact factor: 3.490

10.  Dihydropteridine reductase from Escherichia coli exhibits dihydrofolate reductase activity.

Authors:  S G Vasudevan; B Paal; W L Armarego
Journal:  Biol Chem Hoppe Seyler       Date:  1992-10
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  16 in total

1.  Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli.

Authors:  Hyun Bong Park; Zheng Wei; Joonseok Oh; Hao Xu; Chung Sub Kim; Rurun Wang; Thomas P Wyche; Grazia Piizzi; Richard A Flavell; Jason M Crawford
Journal:  Nat Microbiol       Date:  2020-07-27       Impact factor: 17.745

2.  Pterin and folate salvage. Plants and Escherichia coli lack capacity to reduce oxidized pterins.

Authors:  Alexandre Noiriel; Valeria Naponelli; Jesse F Gregory; Andrew D Hanson
Journal:  Plant Physiol       Date:  2007-01-12       Impact factor: 8.340

3.  Diamide Inhibitors of the Bacillus subtilis N-Acetylglucosaminidase LytG That Exhibit Antibacterial Activity.

Authors:  Saman Nayyab; Mary O'Connor; Jennifer Brewster; James Gravier; Mitchell Jamieson; Ethan Magno; Ryan D Miller; Drew Phelan; Keyana Roohani; Paul Williard; Amit Basu; Christopher W Reid
Journal:  ACS Infect Dis       Date:  2017-05-08       Impact factor: 5.084

Review 4.  Revitalizing antifolates through understanding mechanisms that govern susceptibility and resistance.

Authors:  Shannon Lynn Kordus; Anthony David Baughn
Journal:  Medchemcomm       Date:  2019-05-08       Impact factor: 3.597

5.  Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria.

Authors:  Damien Leduc; Frédéric Escartin; H Frederik Nijhout; Michael C Reed; Ursula Liebl; Stéphane Skouloubris; Hannu Myllykallio
Journal:  J Bacteriol       Date:  2007-09-21       Impact factor: 3.490

6.  A naturally occurring gene amplification leading to sulfonamide and trimethoprim resistance in Streptococcus agalactiae.

Authors:  Mathieu Brochet; Elisabeth Couvé; Mohamed Zouine; Claire Poyart; Philippe Glaser
Journal:  J Bacteriol       Date:  2007-11-16       Impact factor: 3.490

7.  FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa.

Authors:  Anne Pribat; Ian K Blaby; Aurora Lara-Núñez; Jesse F Gregory; Valérie de Crécy-Lagard; Andrew D Hanson
Journal:  J Bacteriol       Date:  2009-11-06       Impact factor: 3.490

8.  Characterization of a novel bifunctional dihydropteroate synthase/dihydropteroate reductase enzyme from Helicobacter pylori.

Authors:  Itay Levin; Moshe Mevarech; Bruce A Palfey
Journal:  J Bacteriol       Date:  2007-04-06       Impact factor: 3.490

9.  Genetic architecture of intrinsic antibiotic susceptibility.

Authors:  Hany S Girgis; Alison K Hottes; Saeed Tavazoie
Journal:  PLoS One       Date:  2009-05-20       Impact factor: 3.240

10.  Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations.

Authors:  Valérie de Crécy-Lagard; Basma El Yacoubi; Rocío Díaz de la Garza; Alexandre Noiriel; Andrew D Hanson
Journal:  BMC Genomics       Date:  2007-07-23       Impact factor: 3.969
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