Literature DB >> 14615072

Dissociable correlates of recollection and familiarity within the medial temporal lobes.

Charan Ranganath1, Andrew P Yonelinas, Michael X Cohen, Christine J Dy, Sabrina M Tom, Mark D'Esposito.   

Abstract

Regions in the medial temporal lobes (MTL) have long been implicated in the formation of new memories for events, however, it is unclear whether different MTL subregions support different memory processes. Here, we used event-related functional magnetic resonance imaging (fMRI) to examine the degree to which two recognition memory processes-recollection and familiarity-were supported by different MTL subregions. Results showed that encoding activity in the rhinal cortex selectively predicted familiarity-based recognition, whereas, activity in the hippocampus and posterior parahippocampal cortex selectively predicted recollection. Collectively, these results support the view that different subregions within the MTL memory system implement unique encoding processes that differentially support familiarity and recollection.

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Year:  2004        PMID: 14615072     DOI: 10.1016/j.neuropsychologia.2003.07.006

Source DB:  PubMed          Journal:  Neuropsychologia        ISSN: 0028-3932            Impact factor:   3.139


  219 in total

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