Literature DB >> 14614158

Flt3 ligand: role in control of hematopoietic and immune functions of the bone marrow.

Aleksandra Wodnar-Filipowicz1.   

Abstract

The concerted action of cytokines secreted locally in the bone marrow controls the maintenance, expansion, and differentiation of hematopoietic stem cells (HSCs), whereas aberrant cytokine signaling contributes to leukemic transformation. Potent effects of flt3 ligand on HSCs and the development of the immune system have generated much interest in the clinical application of this cytokine in stem cell transplantation and cancer immunotherapy.

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Year:  2003        PMID： 14614158     DOI： 10.1152/nips.01452.2003

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  22 in total

Review 1.  Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: pre-clinical and clinical approaches.

Authors:  Ann P Chidgey; Natalie Seach; Jarrod Dudakov; Maree V Hammett; Richard L Boyd
Journal:  Semin Immunopathol       Date:  2008-11-04       Impact factor: 9.623

Review 2.  Emerging strategies to boost thymic function.

Authors:  Georg A Holländer; Werner Krenger; Bruce R Blazar
Journal:  Curr Opin Pharmacol       Date:  2010-05-04       Impact factor: 5.547

3.  Threshold levels of Flt3-ligand are required for the generation and survival of lymphoid progenitors and B-cell precursors.

Authors:  Joseph J Dolence; Kimberly Gwin; Elena Frank; Kay L Medina
Journal:  Eur J Immunol       Date:  2011-02       Impact factor: 5.532

4.  Macrophage differentiation from embryoid bodies derived from human embryonic stem cells.

Authors:  Aparna Subramanian; Beichu Guo; Matthew D Marsden; Zoran Galic; Scott Kitchen; Amelia Kacena; Helen J Brown; Genhong Cheng; Jerome A Zack
Journal:  J Stem Cells       Date:  2009

5.  Efficient production of bioactive recombinant human Flt3 ligand in E. coli.

Authors:  Kenneth Verstraete; Sina Koch; Sevgi Ertugrul; Isabel Vandenberghe; Maarten Aerts; Gonzalez Vandriessche; Christian Thiede; Savvas N Savvides
Journal:  Protein J       Date:  2009-02       Impact factor: 2.371

Review 6.  Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression.

Authors:  Naeem K Patil; Julia K Bohannon; Edward R Sherwood
Journal:  Pharmacol Res       Date:  2016-07-25       Impact factor: 7.658

7.  Flt3 Ligand Treatment Attenuates T Cell Dysfunction and Improves Survival in a Murine Model of Burn Wound Sepsis.

Authors:  Naeem K Patil; Julia K Bohannon; Liming Luan; Yin Guo; Benjamin Fensterheim; Antonio Hernandez; Jingbin Wang; Edward R Sherwood
Journal:  Shock       Date:  2017-01       Impact factor: 3.454

8.  Ectodomain shedding of FLT3 ligand is mediated by TNF-alpha converting enzyme.

Authors:  Keisuke Horiuchi; Hideo Morioka; Hironari Takaishi; Haruhiko Akiyama; Carl P Blobel; Yoshiaki Toyama
Journal:  J Immunol       Date:  2009-06-15       Impact factor: 5.422

9.  Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rγ-/- (NSG) mice.

Authors:  Adam C Drake; Maroun Khoury; Ilya Leskov; Bettina P Iliopoulou; Maria Fragoso; Harvey Lodish; Jianzhu Chen
Journal:  PLoS One       Date:  2011-04-29       Impact factor: 3.240

10.  Correlation of plasma FL expression with bone marrow irradiation dose.

Authors:  Mary Sproull; Dane Avondoglio; Tamalee Kramp; Uma Shankavaram; Kevin Camphausen
Journal:  PLoS One       Date:  2013-03-07       Impact factor: 3.240
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