Literature DB >> 14613181

Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies.

Samuel K Sia1, George M Whitesides.   

Abstract

This review describes microfluidic systems in poly(dimethylsiloxane) (PDMS) for biological studies. Properties of PDMS that make it a suitable platform for miniaturized biological studies, techniques for fabricating PDMS microstructures, and methods for controlling fluid flow in microchannels are discussed. Biological procedures that have been miniaturized into PDMS-based microdevices include immunoassays, separation of proteins and DNA, sorting and manipulation of cells, studies of cells in microchannels exposed to laminar flows of fluids, and large-scale, combinatorial screening. The review emphasizes the advantages of miniaturization for biological analysis, such as efficiency of the device and special insights into cell biology.

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Year:  2003        PMID： 14613181     DOI： 10.1002/elps.200305584

Source DB:  PubMed          Journal:  Electrophoresis        ISSN： 0173-0835            Impact factor:   3.535


  244 in total

1.  Counting cells with a low-cost integrated microfluidics-waveguide sensor.

Authors:  Daniel Garcia; Isaac Ghansah; John Leblanc; Manish J Butte
Journal:  Biomicrofluidics       Date:  2012-03-07       Impact factor: 2.800

2.  Microfluidic carbon-blackened polydimethylsiloxane device with reduced ultra violet background fluorescence for simultaneous two-color ultra violet/visible-laser induced fluorescence detection in single cell analysis.

Authors:  Lukas Galla; Dominik Greif; Jan Regtmeier; Dario Anselmetti
Journal:  Biomicrofluidics       Date:  2012-01-12       Impact factor: 2.800

3.  New rationale for large metazoan embryo manipulations on chip-based devices.

Authors:  Khashayar Khoshmanesh; Jin Akagi; Chris J Hall; Kathryn E Crosier; Philip S Crosier; Jonathan M Cooper; Donald Wlodkowic
Journal:  Biomicrofluidics       Date:  2012-04-03       Impact factor: 2.800

4.  Hydrodynamic trap for single particles and cells.

Authors:  Melikhan Tanyeri; Eric M Johnson-Chavarria; Charles M Schroeder
Journal:  Appl Phys Lett       Date:  2010-06-02       Impact factor: 3.791

Review 5.  Emerging applications of nanotechnology for the diagnosis and management of vulnerable atherosclerotic plaques.

Authors:  Shann S Yu; Ryan A Ortega; Brendan W Reagan; John A McPherson; Hak-Joon Sung; Todd D Giorgio
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2011-08-10

6.  Towards monitoring real-time cellular response using an integrated microfluidics-matrix assisted laser desorption ionisation/nanoelectrospray ionisation-ion mobility-mass spectrometry platform.

Authors:  J R Enders; C C Marasco; A Kole; B Nguyen; S Sevugarajan; K T Seale; J P Wikswo; J A McLean
Journal:  IET Syst Biol       Date:  2010-11       Impact factor: 1.615

7.  Substrate stiffness regulates primary hepatocyte functions.

Authors:  Vaishaali Natarajan; Eric J Berglund; Dorothy X Chen; Srivatsan Kidambi
Journal:  RSC Adv       Date:  2015-09-14       Impact factor: 3.361

8.  Microfluidic chip for isolation of viable circulating tumor cells of hepatocellular carcinoma for their culture and drug sensitivity assay.

Authors:  Yu Zhang; Xiaofeng Zhang; Jinling Zhang; Bin Sun; Lulu Zheng; Jun Li; Sixiu Liu; Guodong Sui; Zhengfeng Yin
Journal:  Cancer Biol Ther       Date:  2016-09-23       Impact factor: 4.742

9.  Tissue engineering toward organ-specific regeneration and disease modeling.

Authors:  Christian Mandrycky; Kiet Phong; Ying Zheng
Journal:  MRS Commun       Date:  2017-07-31       Impact factor: 2.566

10.  Micro-bioreactor arrays for controlling cellular environments: design principles for human embryonic stem cell applications.

Authors:  Elisa Cimetta; Elisa Figallo; Christopher Cannizzaro; Nicola Elvassore; Gordana Vunjak-Novakovic
Journal:  Methods       Date:  2008-10-24       Impact factor: 3.608
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