| Literature DB >> 14611859 |
Vinod R Hegde1, Haiyan Pu, Mahesh Patel, Pradip R Das, Nancy Butkiewicz, Gladys Arreaza, Vincent P Gullo, Tze-Ming Chan.
Abstract
The 70% aq methanolic extract of the Peruvian plant Stylogne cauliflora was found to contain two novel oligophenolic compounds SCH 644343 (1) and SCH 644342 (2), which were identified as inhibitors of HCV NS3 protease. The structure of 1 and 2 was established based on high-resolution NMR studies. Compound 1 inhibited HCV NS3 protease with an IC(50) of 0.3 microM, while compound 2 showed an IC(50) of 0.8 microM.Entities:
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Year: 2003 PMID： 14611859 DOI： 10.1016/s0960-894x(03)00584-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823