Literature DB >> 14607242

Galpha12 and Galpha13 as key regulatory mediator in signal transduction.

Hitoshi Kurose1.   

Abstract

It is generally thought that Galpha(12) and Galpha(13)-induced responses are exclusively mediated by small G protein Rho. However, Galpha(12) and Galpha(13) elicit divergent cellular responses: phospholipase C-epsilon activation, phospholipase D activation, cytoskeletal change, oncogenic response, apoptosis, MAP kinase activation and Na/H-exchange activation. In addition to Rho activation through RhoGEF, it has been recently demonstrated that Galpha(12) and Galpha(13) interact with several proteins and regulate their activities. However, physiological importance of the interaction of Galpha(12) and Galpha(13) with these proteins has not fully established. I summarize the recent progress of Galpha(12) and Galpha(13)-mediated signaling cascade.

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Year:  2003        PMID： 14607242     DOI： 10.1016/j.lfs.2003.09.003

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  36 in total

1.  Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus.

Authors:  Aritoshi Iida; Susumu Saito; Akihiro Sekine; Wataru Tabei; Yukie Kataoka; Yusuke Nakamura
Journal:  J Hum Genet       Date:  2004-06-18       Impact factor: 3.172

Review 2.  Pasteurella multocida toxin as a tool for studying Gq signal transduction.

Authors:  B A Wilson; M Ho
Journal:  Rev Physiol Biochem Pharmacol       Date:  2004-09-29       Impact factor: 5.545

3.  A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.

Authors:  Barry Kreutz; Douglas M Yau; Mark R Nance; Shihori Tanabe; John J G Tesmer; Tohru Kozasa
Journal:  Biochemistry       Date:  2006-01-10       Impact factor: 3.162

Review 4.  Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.

Authors:  Louis M Luttrell
Journal:  Mol Biotechnol       Date:  2008-02-01       Impact factor: 2.695

Review 5.  Role of G12 proteins in oncogenesis and metastasis.

Authors:  Juhi Juneja; Patrick J Casey
Journal:  Br J Pharmacol       Date:  2009-04-30       Impact factor: 8.739

6.  Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII.

Authors:  Lily I Jiang; Julie Collins; Richard Davis; Iain D Fraser; Paul C Sternweis
Journal:  J Biol Chem       Date:  2008-06-09       Impact factor: 5.157

7.  A signaling-regulated, short-chain dehydrogenase of Stagonospora nodorum regulates asexual development.

Authors:  Kar-Chun Tan; Joshua L Heazlewood; A Harvey Millar; Gordon Thomson; Richard P Oliver; Peter S Solomon
Journal:  Eukaryot Cell       Date:  2008-09-05

8.  G alpha12 is targeted to the mitochondria and affects mitochondrial morphology and motility.

Authors:  Alexandra V Andreeva; Mikhail A Kutuzov; Tatyana A Voyno-Yasenetskaya
Journal:  FASEB J       Date:  2008-03-26       Impact factor: 5.191

9.  Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinase-dependent mechanism.

Authors:  John Meshki; Steven D Douglas; Jian-Ping Lai; Lynnae Schwartz; Laurie E Kilpatrick; Florin Tuluc
Journal:  J Biol Chem       Date:  2009-01-28       Impact factor: 5.157

10.  Thrombin-promoted release of UDP-glucose from human astrocytoma cells.

Authors:  S M Kreda; L Seminario-Vidal; C van Heusden; E R Lazarowski
Journal:  Br J Pharmacol       Date:  2008-01-21       Impact factor: 8.739
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