Literature DB >> 14604355

Synthesis of natural ecteinascidins (ET-729, ET-745, ET-759B, ET-736, ET-637, ET-594) from cyanosafracin B.

Roberto Menchaca1, Valentín Martínez, Alberto Rodríguez, Natividad Rodríguez, María Flores, Pilar Gallego, Ignacio Manzanares, Carmen Cuevas.   

Abstract

The semisynthetic process initially described for the synthesis of 1 (ET-743) has been extended to the preparation of other natural ecteinascidins. For the synthesis of 2 (ET-729) a demethylation of a N-Me intermediate was carried out by a selective oxidation with MCPBA. Other natural ecteinascidins (ET-745, ET-759B, ET-736, ET-637, ET-594) were accessible from key intermediate 25. The described methodologies allow for the preparation of a wide variety of ecteinascidins by procedures that can be easily scaled up.

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Year:  2003        PMID： 14604355     DOI： 10.1021/jo034547i

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  7 in total

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Review 3.  Predominately Uncultured Microbes as Sources of Bioactive Agents.

Authors:  David J Newman
Journal:  Front Microbiol       Date:  2016-11-18       Impact factor: 5.640

4.  Synthesis and contractile activity of substituted 1,2,3,4-tetrahydroisoquinolines.

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Review 5.  Cancer wars: natural products strike back.

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6.  Metal-free functionalization of N,N-dialkylanilines via temporary oxidation to N,N-dialkylaniline N-oxides and group transfer.

Authors:  Robert S Lewis; Michael F Wisthoff; J Grissmerson; William J Chain
Journal:  Org Lett       Date:  2014-07-03       Impact factor: 6.005

Review 7.  The Potential of Indonesian Heterobranchs Found around Bunaken Island for the Production of Bioactive Compounds.

Authors:  Katja M Fisch; Cora Hertzer; Nils Böhringer; Zerlina G Wuisan; Dorothee Schillo; Robert Bara; Fontje Kaligis; Heike Wägele; Gabriele M König; Till F Schäberle
Journal:  Mar Drugs       Date:  2017-12-07       Impact factor: 5.118
  7 in total

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