BACKGROUND: in order to describe the prevalence and prognostic implications of chronic bronchitis in individuals 65 years or older we analysed data from The Copenhagen City Heart Study. METHODS: the population was studied in 1976-1978 resurveyed in 1981-1983 and 1991-1994 and followed with regard to survival for up to 12 years. Approximately 3,700 elderly participants with a mean age of 76 years were available for analyses. RESULTS: the prevalence of chronic bronchitis was 13.0% in women and 18.6% in men. Multiple logistic regression yielded the following predictors for chronic bronchitis: male gender (odds ratio with 95% confidence interval = 1.1 (0.9-1.3)), previous smoking odds ratio = 1.7 (1.2-2.2), present smoking odds ratio = 2.1 (2.1-3.8), previous exposure to dusts and fumes (odds ratio = 2.2 (1.7-2.7)), chest infections in childhood (odds ratio = 2.1 (1.6-2.9)), more than 6 chest infections in previous 10 years (odds ratio = 6.2 (4.1-9.2)) and alcohol consumption of more than 3 drinks a day (odds ratio = 1.8 (1.3-2.3)). Chronic bronchitis was a significant predictor of both subsequent respiratory infections and survival. After adjustment for age, smoking and lung function, a Cox regression showed that chronic bronchitis was significantly related to mortality from all causes with a hazard ratio with 95% confidence interval = 1.3 (1.1-1.4), all benign respiratory diseases (hazard ratio = 2.0 (1.6-2.7)), obstructive lung disease (hazard ratio = 2.5 (1.7-3.6)) and lung cancer (hazard ratio = 2.0 (1.4-2.9)). CONCLUSIONS: in an elderly population, chronic bronchitis is a prevalent condition with important prognostic implications.
BACKGROUND: in order to describe the prevalence and prognostic implications of chronic bronchitis in individuals 65 years or older we analysed data from The Copenhagen City Heart Study. METHODS: the population was studied in 1976-1978 resurveyed in 1981-1983 and 1991-1994 and followed with regard to survival for up to 12 years. Approximately 3,700 elderly participants with a mean age of 76 years were available for analyses. RESULTS: the prevalence of chronic bronchitis was 13.0% in women and 18.6% in men. Multiple logistic regression yielded the following predictors for chronic bronchitis: male gender (odds ratio with 95% confidence interval = 1.1 (0.9-1.3)), previous smoking odds ratio = 1.7 (1.2-2.2), present smoking odds ratio = 2.1 (2.1-3.8), previous exposure to dusts and fumes (odds ratio = 2.2 (1.7-2.7)), chest infections in childhood (odds ratio = 2.1 (1.6-2.9)), more than 6 chest infections in previous 10 years (odds ratio = 6.2 (4.1-9.2)) and alcohol consumption of more than 3 drinks a day (odds ratio = 1.8 (1.3-2.3)). Chronic bronchitis was a significant predictor of both subsequent respiratory infections and survival. After adjustment for age, smoking and lung function, a Cox regression showed that chronic bronchitis was significantly related to mortality from all causes with a hazard ratio with 95% confidence interval = 1.3 (1.1-1.4), all benign respiratory diseases (hazard ratio = 2.0 (1.6-2.7)), obstructive lung disease (hazard ratio = 2.5 (1.7-3.6)) and lung cancer (hazard ratio = 2.0 (1.4-2.9)). CONCLUSIONS: in an elderly population, chronic bronchitis is a prevalent condition with important prognostic implications.
Authors: Akkelies E Dijkstra; H Marike Boezen; Maarten van den Berge; Judith M Vonk; Pieter S Hiemstra; R Graham Barr; Kirsten M Burkart; Ani Manichaikul; Tess D Pottinger; Edward K Silverman; Michael H Cho; James D Crapo; Terri H Beaty; Per Bakke; Amund Gulsvik; David A Lomas; Yohan Bossé; David C Nickle; Peter D Paré; Harry J de Koning; Jan-Willem Lammers; Pieter Zanen; Joanna Smolonska; Ciska Wijmenga; Corry-Anke Brandsma; Harry J M Groen; Dirkje S Postma Journal: Eur Respir J Date: 2014-09-18 Impact factor: 16.671
Authors: Akkelies E Dijkstra; Joanna Smolonska; Maarten van den Berge; Ciska Wijmenga; Pieter Zanen; Marjan A Luinge; Mathieu Platteel; Jan-Willem Lammers; Magnus Dahlback; Kerrie Tosh; Pieter S Hiemstra; Peter J Sterk; Avi Spira; Jorgen Vestbo; Borge G Nordestgaard; Marianne Benn; Sune F Nielsen; Morten Dahl; W Monique Verschuren; H Susan J Picavet; Henriette A Smit; Michael Owsijewitsch; Hans U Kauczor; Harry J de Koning; Eva Nizankowska-Mogilnicka; Filip Mejza; Pawel Nastalek; Cleo C van Diemen; Michael H Cho; Edwin K Silverman; James D Crapo; Terri H Beaty; David A Lomas; Per Bakke; Amund Gulsvik; Yohan Bossé; Ma'en Obeidat; M A Obeidat; Daan W Loth; Lies Lahousse; Fernando Rivadeneira; Andre G Uitterlinden; Andre Hofman; Bruno H Stricker; Guy G Brusselle; Cornelia M van Duijn; Uilke Brouwer; Gerard H Koppelman; Judith M Vonk; Martijn C Nawijn; Harry J M Groen; Wim Timens; H Marike Boezen; Dirkje S Postma Journal: PLoS One Date: 2014-04-08 Impact factor: 3.240
Authors: Paul D Blanc; Isabella Annesi-Maesano; John R Balmes; Kristin J Cummings; David Fishwick; David Miedinger; Nicola Murgia; Rajen N Naidoo; Carl J Reynolds; Torben Sigsgaard; Kjell Torén; Denis Vinnikov; Carrie A Redlich Journal: Am J Respir Crit Care Med Date: 2019-06-01 Impact factor: 21.405
Authors: Malin Axelsson; Linda Ekerljung; Jonas Eriksson; Stig Hagstad; Eva Rönmark; Jan Lötvall; Bo Lundbäck Journal: Eur Clin Respir J Date: 2016-07-13