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Literature DB >> 14599590

Covalent immobilization of chitosan and heparin on PLGA surface.

X H Wang¹, D P Li, W J Wang, Q L Feng, F Z Cui, Y X Xu, X H Song.

Abstract

Chitosan and heparin were covalently immobilized onto a poly(lactic acid-co-glycolic acid) (PLGA) surface using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide (EDC), N-hydroxysuccinimide (NHS) in a 2-morpholinoethane sulfonic acid (MES) buffer system. The properties of the modified PLGA surface and the control were investigated by water contact angle measurement and electron spectroscopy for chemical analysis (ESCA). The water contact angle of the modified film was greatly decreased and the element content on the surface of the films changed correspondingly. Platelet adhesion assay showed that blood compatibility of the chitosan/heparin modified film was improved while hepatocyte culture indicated that the cell compatibility of the modified film was enhanced.

Entities: Chemical

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Year: 2003 PMID： 14599590 DOI： 10.1016/s0141-8130(03)00072-2

Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953

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Cited

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Covalent immobilization of chitosan and heparin on PLGA surface.

1. Short-term and long-term effects of orthopedic biodegradable implants.

Review 2. Decoupling polymer properties to elucidate mechanisms governing cell behavior.

3. Anti-inflammatory polymeric coatings for implantable biomaterials and devices.

4. Anti-platelet and tissue engineering approaches to biomaterial blood compatibilization: how well have these been translated into the clinic?

5. Enhancing the stiffness of electrospun nanofiber scaffolds with a controlled surface coating and mineralization.

6. Heparin immobilized porous PLGA microspheres for angiogenic growth factor delivery.

Review 7. Immobilization of heparin: approaches and applications.

8. The mechanics of PLGA nanofiber scaffolds with biomimetic gradients in mineral for tendon-to-bone repair.

9. Recognition of Salmonella Typhimurium by Immobilized Phage P22 Monolayers.

10. Functionalization of titanium with chitosan via silanation: evaluation of biological and mechanical performances.