Literature DB >> 14598219

Cytotoxic and DNA damaging activity of some aporphine alkaloids from Stephania dinklagei.

Ahmet C Gören1, Bing-Nan Zhou, David G Kingston.   

Abstract

Six aporphine alkaloids, liriodenine, corydine, isocorydine, atherospermidine, stephalagine and dehydrostephalagine, were isolated by bioassay-guided fractionation of the EtOH extract of the stems of Stephania dinklagei. Liriodenine showed strong cytotoxic activity while corydine and atherospermidine showed DNA damaging activity. Dehydrostephalagine and atherospermidine were isolated from this plant for the first time.

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Year:  2003        PMID： 14598219     DOI： 10.1055/s-2003-43224

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  6 in total

1.  Assessment of the cytotoxic effects of aporphine prototypes on head and neck cancer cells.

Authors:  Dorival Mendes Rodrigues-Junior; Nicolie Melanie de Almeida Pontes; Gabriela Estrela de Albuquerque; Viviane Carlin; Givago Prado Perecim; Cristiano Raminelli; André Luiz Vettore
Journal:  Invest New Drugs       Date:  2019-05-17       Impact factor: 3.850

2.  Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: an SAR study.

Authors:  Shashikanth Ponnala; Sandeep Chaudhary; Antonio González-Sarrias; Navindra P Seeram; Wayne W Harding
Journal:  Bioorg Med Chem Lett       Date:  2011-06-15       Impact factor: 2.823

Review 3.  Anti-Infective and Anti-Cancer Properties of the Annona Species: Their Ethnomedicinal Uses, Alkaloid Diversity, and Pharmacological Activities.

Authors:  Ari Satia Nugraha; Yuvita Dian Damayanti; Phurpa Wangchuk; Paul A Keller
Journal:  Molecules       Date:  2019-12-03       Impact factor: 4.411

Review 4.  Advocacy for the Medicinal Plant Artabotrys hexapetalus (Yingzhao) and Antimalarial Yingzhaosu Endoperoxides.

Authors:  Christian Bailly; Jean-Pierre Hénichart
Journal:  Molecules       Date:  2022-09-21       Impact factor: 4.927

5.  Therapeutic Potential of Plants as Anti-microbials for Drug Discovery.

Authors:  Ramar Perumal Samy; Ponnampalam Gopalakrishnakone
Journal:  Evid Based Complement Alternat Med       Date:  2008-06-24       Impact factor: 2.629

6.  Zanthoxoaporphines A-C: Three new larvicidal dibenzo[de,g]quinolin-7-one alkaloids from Zanthoxylum paracanthum (Rutaceae).

Authors:  Fidelis N Samita; Louis P Sandjo; Isaiah O Ndiege; Ahmed Hassanali; Wilber Lwande
Journal:  Beilstein J Org Chem       Date:  2013-02-27       Impact factor: 2.883
  6 in total

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