Literature DB >> 14598211

Cytotoxic alkaloids from Boehmeria siamensis.

Yinggang Luo1, Yan Liu, Dixiang Luo, Xiaoping Gao, Bogang Li, Guolin Zhang.   

Abstract

Two new phenanthroquinolizidine alkaloids, boehmeriasins A and B, were isolated from the aqueous ethanolic extract of Boehmeria siamensis Craib (Urticaceae) by bioassay-guided fractionation. Their structures were elucidated on the basis of spectral evidence. Boehmeriasin A possesses cytotoxic activity against 12 cell lines from 6 panels of cancer including lung cancer, colon cancer, breast cancer, prostate cancer, kidney cancer and leukemia with GI (50) between 0.2 and 100 ng/mL, whereas boehmeriasin B showed lower activity.

Entities:  

Mesh:

Substances:

Year:  2003        PMID: 14598211     DOI: 10.1055/s-2003-43215

Source DB:  PubMed          Journal:  Planta Med        ISSN: 0032-0943            Impact factor:   3.352


  7 in total

1.  Anti-hepatitis B virus activity of Boehmeria nivea leaf extracts in human HepG2.2.15 cells.

Authors:  Jingchen Wei; Lianku Lin; Xiaojian Su; Shaoyan Qin; Qing Xu; Zunian Tang; Yan Deng; Yuehan Zhou; Songqing He
Journal:  Biomed Rep       Date:  2013-11-22

2.  Chemopreventive effect of piperine on mitochondrial TCA cycle and phase-I and glutathione-metabolizing enzymes in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice.

Authors:  K Selvendiran; C Thirunavukkarasu; J Prince Vijeya Singh; R Padmavathi; D Sakthisekaran
Journal:  Mol Cell Biochem       Date:  2005-03       Impact factor: 3.396

3.  Total Syntheses and Cytotoxicity of (R)- and (S)-Boehmeriasin A.

Authors:  Matthew W Leighty; Gunda I Georg
Journal:  ACS Med Chem Lett       Date:  2011-04-14       Impact factor: 4.345

4.  Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus.

Authors:  Cheng-Wei Yang; Yue-Zhi Lee; Iou-Jiun Kang; Dale L Barnard; Jia-Tsrong Jan; Du Lin; Chun-Wei Huang; Teng-Kuang Yeh; Yu-Sheng Chao; Shiow-Ju Lee
Journal:  Antiviral Res       Date:  2010-08-19       Impact factor: 5.970

Review 5.  Possible pharmaceutical applications can be developed from naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids.

Authors:  Xian-Hui Jia; Huan-Xin Zhao; Cheng-Lin Du; Wen-Zhao Tang; Xiao-Jing Wang
Journal:  Phytochem Rev       Date:  2020-09-25       Impact factor: 7.741

6.  First discovery and stucture-activity relationship study of phenanthroquinolizidines as novel antiviral agents against tobacco mosaic virus (TMV).

Authors:  Ziwen Wang; Anzheng Feng; Mingbo Cui; Yuxiu Liu; Lizhong Wang; Qingmin Wang
Journal:  PLoS One       Date:  2012-12-28       Impact factor: 3.240

7.  Use of chiral-pool approach into epi-thieno analogues of the scarce bioactive phenanthroquinolizidine alkaloids.

Authors:  Peter Šafář; Štefan Marchalín; Nadežda Prónayová; Viktor Vrábel; Ata Martin Lawson; Mohamed Othman; Adam Daïch
Journal:  Tetrahedron       Date:  2016-04-21       Impact factor: 2.457

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.