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Literature DB >> 14595672

The thioredoxin system--from science to clinic.

Stephan Gromer¹, Sabine Urig, Katja Becker.

Abstract

The thioredoxin system-formed by thioredoxin reductase and its characteristic substrate thioredoxin-is an important constituent of the intracellular redox milieu. Interactions with many different metabolic pathways such as DNA-synthesis, selenium metabolism, and the antioxidative network as well as significant species differences render this system an attractive target for chemotherapeutic approaches in many fields of medicine-ranging from infectious diseases to cancer therapy. In this review we will present and evaluate the preclinical and clinical results available today. Current trends in drug development are emphasized. Copyright 2003 Wiley Periodicals, Inc.

Entities: Chemical Disease Gene

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Year: 2004 PMID： 14595672 DOI： 10.1002/med.10051

Source DB: PubMed Journal: Med Res Rev ISSN： 0198-6325 Impact factor: 12.944

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Cited

92 in total

1. The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities.

Authors: Qing Cheng; William E Antholine; Judith M Myers; Balaraman Kalyanaraman; Elias S J Arnér; Charles R Myers
Journal: J Biol Chem Date: 2010-05-10 Impact factor: 5.157

2. Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni.

Authors: Hsin-Hung Huang; Latasha Day; Cynthia L Cass; David P Ballou; Charles H Williams; David L Williams
Journal: Biochemistry Date: 2011-06-10 Impact factor: 3.162

3. Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets.

Authors: Anton A Turanov; Sebastian Kehr; Stefano M Marino; Min-Hyuk Yoo; Bradley A Carlson; Dolph L Hatfield; Vadim N Gladyshev
Journal: Biochem J Date: 2010-09-01 Impact factor: 3.857

4. Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells.

Authors: Yi-Hua Jan; Diane E Heck; Joshua P Gray; Haiyan Zheng; Robert P Casillas; Debra L Laskin; Jeffrey D Laskin
Journal: Chem Res Toxicol Date: 2010-06-21 Impact factor: 3.739

10. Solution structures of Mycobacterium tuberculosis thioredoxin C and models of intact thioredoxin system suggest new approaches to inhibitor and drug design.

Authors: Andrew L Olson; Terrence S Neumann; Sheng Cai; Daniel S Sem
Journal: Proteins Date: 2013-01-15

The thioredoxin system--from science to clinic.

1. The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities.

2. Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni.

3. Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets.

4. Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells.

5. Nrf2 target genes are induced under marginal selenium-deficiency.

6. Persistently low plasma thioredoxin is associated with meningococcal septic shock in children.

7. Thiol-Redox Regulation in Lung Development and Vascular Remodeling.

8. Selective inhibition of extracellular thioredoxin by asymmetric disulfides.

Review 9. Focus on antioxidant enzymes and antioxidant strategies in smoking related airway diseases.

10. Solution structures of Mycobacterium tuberculosis thioredoxin C and models of intact thioredoxin system suggest new approaches to inhibitor and drug design.